Difference between revisions of "Joint Response to Injury"

Latest revision as of 16:43, 3 March 2011

Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
  - Chondrocyte hyperplasia is ineffective at filling the defect
  - Non-painful
- Defects reaching subchondral bone
  - Filled with vascular fibroous tissue undergoing metaplasia into cartilage
  - Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
Synovial membranes respond by:
- Villous hypertrophy
  - +/- synovitis
- Hyperplasia

@@ Line 1: / Line 1: @@
-{{toplink
+===Causes of injury ===
-|backcolour =CDE472
-|linkpage =Musculoskeletal System - Pathology
+*Trauma
-|linktext =Musculoskeletal System
+*Instability
-|maplink = Musculoskeletal System (Content Map) - Pathology
+*Lubrication failure
-|pagetype =Pathology
+*Infectious organisms
-|sublink1=Joints - Pathology
+*Immune-mediated disease
-|subtext1=JOINTS
-}}
+===Reaction to injury===
-<br>
+*[[Joints - Anatomy & Physiology#Articular cartilage|Articular cartilage]] has limited ability to regenerate
+**Superficial defects are long standing
+***Chondrocyte hyperplasia is ineffective at filling the defect
+***Non-painful
+**Defects reaching subchondral bone
+***Filled with vascular fibroous tissue undergoing [[Cell Growth Disorders#Metaplasia|metaplasia]] into cartilage
+***Painful
+**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
+**Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
+*Synovial membranes respond by:
+**Villous hypertrophy
+***+/- synovitis
+**Hyperplasia
+[[Category:Joints - Pathology|A]]