Difference between revisions of "CNS Traumatic Injury - Pathology"

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==[[Concussion]]==
+
#redirect[[:Category:Central Nervous System - Traumatic Injury]]
 
 
 
 
 
 
==[[Contusion of Central Nervous System]] ==
 
 
 
 
 
 
 
 
 
==Laceration==
 
 
 
* Tearing of the CNS is known as lacreation.
 
* This may be caused by
 
** Bone within the skull
 
*** For example, a fractured skull
 
** Penetrating objects
 
*** For example, bullets.
 
* Laceration is the most severe and serious form of traumatic injury as it carries the additional risk of contamination or infection.
 
 
 
 
 
[[Category:Central Nervous System - Traumatic Injury]]
 
 
 
==Haemorrhage==
 
 
 
* Haemorrhage may:
 
** Follow contusion injury
 
** Result from endothelial damage
 
* Locations of haemorrhage may be:
 
** Epidural
 
** Subdural
 
** Leptomeningeal
 
** Cerebral
 
 
 
 
 
[[Category:Central Nervous System - Traumatic Injury]]
 
 
 
 
 
==Compression==
 
 
 
* Compression may arise within or outside the spinal cord.
 
* Causes of compression include:
 
** '''Abscess'''
 
*** Abscesses may be extradural, vertebral or intervertebral.
 
** '''Fracture of vertebral bodies'''
 
*** Traumatic fracture
 
*** Pathological fracture, due to abscess, metabolic causes or neoplasia.
 
** '''Neoplasia'''
 
** '''Intervertebral disk disease'''
 
*** Prolapsed disks can cause acute or chronic compression.
 
** '''Malformations '''
 
*** Wobbler [[Equine Alimentary System  - Anatomy & Physiology|horses]]
 
**** Caused by stenotic myelopathy.
 
**** The vertebral canal narrows due to malformation and malarticulation of the cervical vertebrae (usually C3-C4)
 
*** Cervical vertebral malformation-malarticulation in dogs has a similar pathogenesis to wobbler [[Equine Alimentary System  - Anatomy & Physiology|horses]]
 
*** Atlantoaxial subluxation of toy dogs.
 
**** A hypoplastic dens leads to subluxation.
 
 
 
===Pathology===
 
 
 
* Lesions associated with focal compressive spinal cord injury are similar regardless of cause.
 
 
 
====Gross====
 
 
 
* The spinal cord may be indented or flattened.
 
 
 
====Histological====
 
 
 
* The myelin sheath may balloon in all funiculi.
 
* Axonal swelling and loss is seen.
 
* Macrophages appear within days and remove debris within myelin "digestion chambers".
 
* Neuronal loss, gliosis, malacia and oedema may also be apparent.
 
 
 
 
 
[[Category:Central Nervous System - Traumatic Injury]]
 

Latest revision as of 13:05, 8 March 2011