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Caused by ''[[Dictyocaulus viviparus]]''
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== Introduction<br> ==
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==== Epidemiology of Parasitic Bronchitis ====
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Parasitic Bronchitis in cattle is caused by the lungworm ''[[Dictyocaulus viviparus]]''.
Our knowledge of the epidemiology of disease is far from complete, i.e. there are still outbreaks of parasitic bronchitis that we are unable to explain.
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''Disease is carried on from one year to the next by''
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Our knowledge of the epidemiology of disease is far from complete, i.e. there are still outbreaks of parasitic bronchitis that we are unable to explain.
*Low numbers of L3 overwintering on pasture
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*Carrier animals (30% yearlings and 5% cows in an endemic area)
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''Sequence of events that leads up to an outbreak of clinical disease is as follows''
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Disease is carried on from one year to the next by, low numbers of L3 overwintering on pasture and from carrier animals (30% yearlings and 5% cows in an endemic area). The sequence of events that leads up to an outbreak of clinical disease are; a few calves in a group pick up overwintered L3 from pasture after turnout, leading to patent infections; the&nbsp;L1 develop to L3 in a dungpat. Then translation of L3 onto the pasture, which is largely by fungus (''Pilobilus'' species) occurs. The remainder of calves are then infected. The infection may cycle 1, 2 or more times before sufficient L3 accumulate on pasture to cause disease (July – September). A large proportion of ingested larvae become inhibited in lungs of calves overwinter, leading to pasture contamination following spring turnout, i.e. “carrier animals”.  
*A few calves in a group pick up overwintered L3 from pasture after turnout, leading to patent infections
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*L1 develop to L3 in dungpat
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*Translation of L3 onto the pasture largely by fungus (''Pilobilus'' species)
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*Remainder of calves infected. The infection may cycle 1, 2 or more times before sufficient L3 accumulate on pasture to cause disease (July – September)
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*Large proportion of ingested larvae become inhibited in lungs of calves overwinter, leading to pasture contamination following spring turnout, i.e. “carrier animals”.
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''Immunity''
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Immunity is rapidly acquired following heavy exposure to infection (within a few weeks). There is minimal age resistance with older stock being susceptible if not previously exposed.
*Rapidly acquired following heavy exposure to infection (within a few weeks)
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*Minimal age resistance (i.e. older stock susceptible if not previously exposed)
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==== Pathogenesis of Parasitic Bronchitis ====
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The primary infection has a penetration period of one week. Here, the larvae migrate to the lungs and there are no clinical signs. The prepatent period is then one to three weeks and involves the development and migration of larvae. This lead to to bronchiolitis, which produces an eosinophilic exudate. This blocks the passage of air leading to alveolar collapse distal to blockage. The Patent Phase (weeks 4-8), is when the worms mature and become egg-producing. The main lesions are bronchitis (due to adult worms) and parasitic pneumonia (due to aspiration of eggs and larvae → cellular infiltration of polymorphs, macrophages and “foreign body” giant cells). The postpatent Phase (weeks 8-12) is the period at the end of disease when the majority of worms are expelled. In 25% of cases, clinical signs flare up as a result of alveolar epithelialisation, which may be accompanied by interstitial emphysema and pulmonary oedema, or secondary bacterial infection.
'''Primary Infection'''
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''Penetration Phase (week 1)''
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Reinfection Syndrome occurs in immune cattle. They will only show clinical signs if exposed to a massive challenge; large numbers of larvae reach bronchioles and are killed by immune response<br> <br>
*Larvae migrate to the lungs; no clinical signs.
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''Prepatent Phase (weeks 1-3)''
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== Clinical Signs<br> ==
*Development and migration of larvae → bronchiolitis → eosinophilic exudate → blocks passage of air → alveolar collapse distal to blockage → clinical signs (tachypnoea, coughing depending on the number of worms)
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''Patent Phase (weeks 4-8)''
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Clinical signs include tachypnoea, coughing (depending on the number of worms) and an increased respiratory rate. <br>
*Worms mature and become egg-producing. Main lesions are
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**Bronchitis (due to adult worms)
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**Parasitic pneumonia (due to aspiration of eggs and larvae → cellular infiltration of polymorphs, macrophages and “foreign body” giant cells)
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''Postpatent Phase (weeks 8-12)''
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<br>
*Period at the end of disease when the majority of worms are expelled. In 25% of cases, clinical signs flare up as a result of alveolar epithelialisation, which may be accompanied by interstitial emphysema and pulmonary oedema, or secondary bacterial infection
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'''Reinfection Syndrome'''
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== Diagnosis of Parasitic Bronchitis (Calves) ==
*Immune cattle only show clinical signs if exposed to a massive challenge
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*Pathogenesis; large numbers of larvae reach bronchioles → killed by immune response
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*Pathology; parasite granulomata (grey-green, 5mm diameter; macrophages, giant cells, eosinophils) and eosinophilic plugs in bronchioles
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==== Diagnosis of Parasitic Bronchitis (Calves) ====
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Diagnosis is based on the seasonal incidence, previous grazing history and clinical signs. Definitive diagnosis can be gained by performing a Baerman technique on a faecal sample to identify larvae. Samples need to be taken from both healthy and sick cattle as carrier animals may be important in the epidemiology of disease, e.g. in an endemic area 30% yearlings and 5% cows harbour patent infections, as do vaccinated animals. '''NOTE''': All lungworm-positive faecal samples are potentially significant.
*Seasonal incidence
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*Previous grazing history
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*Clinical signs
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*Faecal examination for larvae
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**Baerman technique; examine both healthy and sick cattle
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**Carrier animals may be important in the epidemiology of disease, e.g. in an endemic area 30% yearlings and 5% cows harbour patent infections, as do vaccinated animals
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'''NOTE''': All lungworm-positive faecal samples are potentially significant  
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*''Post mortem'' examination
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Post mortem examination can also be diagnositc; recovery of worms from lungs by the “Inderbitzen” or lung perfusion technique. Worms are flushed out of lungs by pumping water through pulmonary arteries. Water and worms passed out of trachea collected over sieve. '''NOTE''': Only 200-300 worms are required to cause clinical disease c.f. &gt;40,000 ''Ostertagia''
**Recovery of worms from lungs; “Inderbitzen” or lung perfusion technique. Worms flushed out of lungs by pumping water through pulmonary arteries. Water and worms passed out of trachea collected over sieve  
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<br>
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'''NOTE''': Only 200-300 worms are required to cause clinical disease c.f. >40,000 ''Ostertagia''
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== Diagnosis of Parasitic Bronchitis (Adult Cattle)  ==
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==== Diagnosis of Parasitic Bronchitis (Adult Cattle) ====
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Diagnosis is again based on seasonal incidence, previous grazing history and clinical signs. Definitive diagnosis can be achieved by faecal examination using the Baerman technique to identiy larvae. Both healthy and sick cattle should be examined. Blood and Milk examination (ELISA) to look for antibodies can be used, but this has variable results (depending upon Ag used). Herd results are better than individual results in this case.<br>
*Seasonal incidence
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*Previous grazing history
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*Clinical signs
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*Faecal examination  
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**Baerman technique; examine healthy and sick cattle, but often no larvae in faeces
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*Blood and Milk examination (ELISA)  
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**Variable results (depending upon Ag used)
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**Herd results better than individual results
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*Grass examination for larvae around dung pats
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*Response to anthelmintic treatment
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==== Control of Parasitic Bronchitis ====
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Grass examination for larvae around dung pats is useful. Response to anthelmintic treatment will provide a retrospective diagnosis.<br>
'''Vaccination – “Huskvac” (Intervet, original vaccine = “Dictol”)'''
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*First-season calves, >2months old, reared indoors
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*Attenuated oral vaccine (each dose, 1,000 X-irradiated ''Dictyocaulus viviparus'' L3)
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*Vaccinate 6 weeks and 2 weeks pre-turnout
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'''NOTE''': '''Never''' mix vaccinated and non-vaccinated animals
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<br>
*Result:
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**Effective at preventing disease
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**Not 100% effective at preventing infection, i.e. even vaccinated calves may pass a few larvae → boost immunity in vaccinated calves, but could cause disease in non-vaccinated animals
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*Breakdown in protection can occur due to:
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**Overwhelming challenge
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**Improper storage or administration of vaccine
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**Concurrent disease
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**Mixing vaccinated and non-vaccinated calves
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*Strategic anthelmintic programmes for preventing parasitic bronchitis:
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**Ivermectin 3, 8 and 13 week post-turnout treatment
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'''NOTE''': Residual activity of 28 days against lungworm
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== Treatment and Control&nbsp;  ==
*No anthelmintic cover if challenge encountered either:
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**early (0-3 weeks) or
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**late (after 17 weeks) in grazing season.
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==Test yourself with the Cattle Nematode Flashcards==
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'''Vaccination – “Huskvac” (Intervet, original vaccine = “Dictol”)'''
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[[Cattle_Nematode_Flashcards|Cattle_Nematode Flashcards]]
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Should be given to first-season calves, &gt;2months old, reared indoors. It is an attenuated oral vaccine (each dose, 1,000 X-irradiated ''Dictyocaulus viviparus'' L3). Vaccination is required at 6 weeks of age and again at 2 weeks pre-turnout. '''NOTE''': '''Never''' mix vaccinated and non-vaccinated animals. The vaccine in effective at preventing disease, although not 100% effective at preventing infection, i.e. even vaccinated calves may pass a few larvae → boost immunity in vaccinated calves, but could cause disease in non-vaccinated animals. A breakdown in protection can occur due to overwhelming challenge, improper storage or administration of vaccine, concurrent disease and mixing vaccinated and non-vaccinated calves. Therefore other control measures such as trying to keep a clean pasture and following instructions are very important. <br>
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[[Category:Respiratory Diseases - Cattle]]
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'''Strategic anthelmintic programmes '''for preventing parasitic bronchitis can also be used. This will entail Ivermectin being administered at 3, 8 and 13 weeks post-turnout. '''NOTE''': Residual activity of 28 days against lungworm. There will be no anthelmintic cover if challenge encountered either early (0-3 weeks) or late (after 17 weeks) in the grazing season. <br>
[[Category:To_Do_-_Clinical]]
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== References<br> ==
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Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing<br>Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition) Elsevier Science<br>Divers, T.J. and Peek, S.F. (2008) Rebhun's diseases of dairy cattle Elsevier Health Scieneces<br>Fox, M and Jacobs, D. (2007) Parasitology Study Guide Part 2: Helminths Royal Veterinary College<br>Merck &amp; Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial<br>Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences<br>
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== Test yourself with the Cattle Nematode Flashcards ==
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[[Cattle Nematode Flashcards|Cattle_Nematode Flashcards]]
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[[Category:Respiratory_Diseases_-_Cattle]] [[Category:To_Do_-_Review]]
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