Difference between revisions of "Transmissible Gastroenteritis Virus"

Revision as of 18:20, 23 March 2011

Synonyms

TGEV, TGE or epidemic diarrhoea.

Introduction

TGEV is an enteric coronavirus, of which there is only one serotype. It is now rare in Europe, due to a respiratory coronavirus variant which is now prevalent and is thought to provide immunity to TGEV.

Pigs are particularly susceptible to a number of specific enteric viruses, especially coronaviruses. These may produces outbreaks on a whole farm basis in all ages of pigs. TGEV produces an explosive diarrhoeic disease, which spreads through the farm rapidly. There is a mlabsoprtive diarrhoea, which affects neonates and can be fatal depending on age and immune status of the piglet. In very young pigs the virus can rach 100% mortality, whereas in pigs over 5 weeks of age it is rarely fatal.

There is severe villus stunting present in the intestines, which is similar in pathological appearance to rotavirus. The lamnia propria is congested and oedemetous. These changes are in contrast to coliform infections, which show much more normal villi. Many gram-negative bacteria can be seen adhering to the villi wall if a gram stain is used and this can contribute to the disease, with secondary bacterial infection making clinical signs more severe.

The virus is highly contagious and is spread by orofaecal transmission. The infection can occur in two forms, firstly, epizootic, where an explosive infection occurs following introduction to a non-immune herd. Enzootic infection occurs when a herd is persistantly affected.

Immune sows provide passive immunity but piglets will suffer mild symptoms post-weaning.

Signalment

Pigs only. It can affect other species but is not a disease problem in these. All ages are susceptable but younger pigs are more severely affected. In pigs less than 2 weeks of age the disease is usually fatal. In pigs older than around 5 weeks, pigs will usually recover.

Clinical Signs

Signs include very severe malabsorptive diarrhoea, depression, lethargy, weakness, dehydration and death.

Diagnosis

Diagnosis is best performed by fluorescent microscopy on small intestinal sections.

Treatment and Control

In an epizootic outbreak, where immune sows are not present in the herd, it is important to seperate sows that are due to farrow down within two weeks immediately from the rest of the herd if this is not already the case. Then, the herd should be immunised by exposing them to infected stock. Disease will only be mild in older pigs, so immunising them in this way reduces the risk of the fatal form of the disease in piglets.

There is no effective vaccine.

References

Cowart, R.P. and Casteel, S.W. (2001) An Outline of Swine diseases: a handbook, Wiley-Blackwell
Jackson, G.G. and Cockcroft, P.D. (2007) Handbook of Pig Medicine, Saunders Elsevier
Straw, B.E. and Taylor, D.J. (2006) Disease of Swine, Wiley-Blackwell

@@ Line 1: / Line 1: @@
-{{unfinished}}
+== Synonyms ==
-Also known as: TGEV, TGE
+TGEV, TGE or epidemic diarrhoea.
-* Pigs are particularly susceptible to a number of specific enteric viruses.
-** Especially coronaviruses.
-*** These may produces outbreaks on a whole farm basis in all ages of pigs.
-====Antigenicity====
+== Introduction ==
-*Single serotype
-====Hosts====
+TGEV is an enteric coronavirus, of which there is only one serotype. It is now rare in Europe, due to a respiratory coronavirus variant which is now prevalent and is thought to provide immunity to TGEV.
-*Pigs
-====Pathogenesis====
+Pigs are particularly susceptible to a number of specific enteric viruses, especially coronaviruses. These may produces outbreaks on a whole farm basis in all ages of pigs. TGEV produces an explosive diarrhoeic disease, which spreads through the farm rapidly. There is a mlabsoprtive diarrhoea, which affects neonates and can be fatal depending on age and immune status of the piglet. In very young pigs the virus can rach 100% mortality, whereas in pigs over 5 weeks of age it is rarely fatal.
-*Malabsorptive diarrhoea
-*All ages susceptible but effects vary on age:
-**Less than 2 weeks of age: typically fatal
-**Over 5 weeks of age: recovery and immunity
-====Epidemiology====
+There is severe villus stunting present in the intestines, which is similar in&nbsp;pathological appearance to rotavirus.&nbsp;The lamnia propria is congested and oedemetous.&nbsp;These changes are in contrast to coliform infections, which show much more normal villi. Many gram-negative bacteria can be seen adhering to the villi wall if a gram stain is used and this can contribute to the disease, with secondary bacterial infection making clinical signs more severe.
-*Largely replaced by a respiratory variant in Europe
-*Highly contagious spread by '''orofecal''' transmission
-*Two forms of infection can occur:
-**'''Epizootic''': Explosive infection
-***Introduction to a non-immune herd spreads quickly
-**'''Enzootic''': Persistent infection
-***Immune sows provide passive immunity but piglets will suffer mild symptoms post-weaning
-====Diagnosis====
+The virus is highly contagious and is spread by orofaecal transmission. The infection can occur in two forms, firstly, epizootic, where an explosive infection occurs following introduction to a non-immune herd. Enzootic infection occurs when a herd is persistantly affected.
-*Fluorescent microscopy on SI sections
-====Control====
+Immune sows provide passive immunity but piglets will suffer mild symptoms post-weaning.
-Explosive infection:
-*Separate sows 2 weeks from farrowing
-*Exposure of flock will serve to immunise
-*No effective vaccines exist
+== <br>Signalment ==
-* Caused by a [[Coronaviridae|coronavirus]].
+Pigs only. It can affect other species but is not a disease problem in these. All&nbsp;ages are susceptable but younger pigs are more severely affected.&nbsp;In pigs less than 2 weeks of age the disease is usually fatal. In pigs older than around 5 weeks, pigs will usually recover.
-* Known as Epidemic diarrhoea or TGE.
-* Produces an explosive diarrhoeic disease, which spreads through the farm rapidly.
-* Epidemiologically, the disease is easy to recognise, since all ages of pigs scour.
-** This is the means of diagnosis.
-* Consequences of disease differ with the age of the animal.
-** In very young animals, mortality may be up to 100%.
-** In animals 1-3 weeks old, mortality is around 50%.
-** Over 3 weeks of aged, mortality is 25%.
-** Older pigs tend to recover from the disease.
-=====Pathology=====
-* Villi are shortened and more rounded, with a degree of fusion.
-* Epithelial cells over the villi are flattened.
-* The lamnia propria is congested and oedemetous.
-* These changes are in contrast to coliform infections, which show much more normal villi.
-** Many gram-negative bacteria can be seen adhering to the villi wall if a gram stain is used.
-[[Category:Coronaviridae]][[Category:Pig Viruses]][[Category:Intestinal Diseases - Pig]]
+== Clinical Signs ==
-[[Category:Enteritis,_Catarrhal]][[Category:Enteritis,_Viral]]
-[[Category:To_Do_-_Clinical/Viruses]]
+Signs include very severe malabsorptive diarrhoea, depression, lethargy, weakness, dehydration and death.
+== Diagnosis ==
+Diagnosis is best performed by fluorescent microscopy on small intestinal sections.
+== Treatment and&nbsp;Control ==
+In an epizootic outbreak, where immune sows are not present in the herd, it is important to seperate sows that are due to farrow down within two weeks immediately from the rest of the herd if this is not already the case. Then, the herd should be immunised by exposing them to infected stock. Disease will only be mild in older pigs, so immunising them in this way reduces the risk of the fatal form of the disease in piglets.
+There is no effective vaccine.
+== References ==
+Cowart, R.P. and Casteel, S.W. (2001) An Outline of Swine diseases: a handbook, Wiley-Blackwell <br>Jackson, G.G. and Cockcroft, P.D. (2007) Handbook of Pig Medicine, Saunders Elsevier <br>Straw, B.E. and Taylor, D.J. (2006) Disease of Swine, Wiley-Blackwell <br>
+<br>
+[[Category:Coronaviridae]] [[Category:Pig_Viruses]] [[Category:Intestinal_Diseases_-_Pig]] [[Category:Enteritis,_Catarrhal]] [[Category:Enteritis,_Viral]] [[Category:To_Do_-_Review]]