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Line 1: |
| − |
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| | *No causative agent has been found | | *No causative agent has been found |
| | *Seem to be immune-mediated diseases | | *Seem to be immune-mediated diseases |
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| | ===Erosive=== | | ===Erosive=== |
| | | | |
| − | ====Rheumatoid arthritis==== | + | ====[[Rheumatoid Arthritis]]==== |
| − | *Occurs in the dog, mainly smaller breeds
| |
| − | *Uncommon
| |
| − | *Progressive erosive polyarthritis
| |
| − | *Mostly involves elbows, stifles, carpal and tarsal joints
| |
| − | *Grossly:
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| − | **Marked villus hypertrophy of synovial membrane
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| − | **Cartilage erosion
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| − | **[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation
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| − | **In severe cases ankylosis
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| − | *Histologically:
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| − | **Hyperplasia of lining cells
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| − | **Proliferative synovitis
| |
| − | **Synovial membrane has fibrin deposits
| |
| − | **Lymphoid and plasma cell infiltration
| |
| − | **Surrounding haemorrhagic areas
| |
| − | **Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]]
| |
| − | **Connective tissue may contain foci of necrosis
| |
| − | **Areas of erosion of peripheral articular cartilage and underlying subchondral bone
| |
| − | *Pathogenesis:
| |
| − | **May involve deposition of immune complexes within joints
| |
| − | **Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation
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| | **Anaemia | | **Anaemia |
| | **Thrombocytopaenia | | **Thrombocytopaenia |
| − | **[[Muscles Inflammatory - Pathology#Myositis|Polymyositis]] | + | **[[:Category:Muscles - Inflammatory Pathology|Polymyositis]] |
| − | **[[Kidney Glomerular Disease - Pathology#Glomerulonephritis|Glomerulonephritis]] | + | **[[Glomerulonephritis|Glomerulonephritis]] |
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| | ====Gout==== | | ====Gout==== |
| | | | |
| − | *Occurs in humans, reptiles and birds (have no uricase enzyme) | + | *Occurs in humans, [[Snake Gout|reptiles]] and birds (have no uricase enzyme) |
| | *The urate triggers inflammation | | *The urate triggers inflammation |
| | | | |
| | [[Category:Arthritis]] | | [[Category:Arthritis]] |