Changes

Adrenal dependant disease may be unresponsive to ACTH.  

Adrenal dependant disease may be unresponsive to ACTH.  

'''Low dose dexamethasone test''': Will reliably differentiate between normal and hyperadrenocorticism dogs. Sample before and 3 and 8 hours after i/v dexamethasone at 0.01mg/kg. Normal and dogs with pituitary dependant disease show suppression of cortisol production to <50% at 3 hours whereas dogs with adrenal dependant disease have high cortisol levels which are not suppressed.

'''Low dose dexamethasone test''': Will reliably differentiate between normal and hyperadrenocorticism dogs. Sample before and 3 and 8 hours after i/v dexamethasone at 0.01mg/kg (Bexfield and Lee, 2010). Normal dogs and dogs with pituitary dependant disease show suppression of cortisol production to <50% at 3 hours whereas dogs with adrenal dependant disease have high cortisol levels which are not suppressed.

'''High dose dexamethasone test''': Distinguishes pituitary and adrenal dependant disease once Cushings has been diagnosed. Dexamethasone dose is 0.1mg/kg. Pituitary dependant disease will show suppression of cortisol production due to negative feedback at the pituitary whereas adrenal dependant disease will not.

'''High dose dexamethasone test''': This test is used to distinguish pituitary and adrenal dependant disease in dogs once Cushings has been diagnosed and can help with diagnosis in cats. Dexamethasone dose is 0.1mg/kg (Bexfield and Lee, 2010). Pituitary dependant disease will show suppression of cortisol production due to negative feedback at the pituitary whereas adrenal dependant disease will not.

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== References ==

== References ==

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.

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