Changes

*''B. bronchiseptica'' causes [[Nasal Cavity Inflammatory - Pathology#Bacterial rhinitis|Atrophic rhinitis of pigs]] in association with [[Pasteurella multocida|''Pasteurella multocida'']]

*''B. bronchiseptica'' causes [[Rhinitis#Bacterial rhinitis|Atrophic rhinitis of pigs]] in association with [[Pasteurella multocida|''Pasteurella multocida'']]

*Colonises nasopharynx

*Colonises nasopharynx

*Infection must occur during first few weeks of life

*Infection must occur during first few weeks of life

*Produces dermonecrotic toxin which damages osteoblasts, preventing bone formation

*Produces dermonecrotic toxin which damages osteoblasts, preventing bone formation

*Leads to turbinate atrophy without distortion of the snout in uncomplicated infections

*Leads to turbinate atrophy without distortion of the snout in uncomplicated infections

*[[Nasal Cavity Inflammatory - Pathology#Bacterial rhinitis|Atrophic rhinitis]] results when [[Pasteurella multocida|''Pasteurella multocida'']] colonises and produces osteolytic toxin, leading to bone resorption

*[[Rhinitis#Bacterial rhinitis|Atrophic rhinitis]] results when [[Pasteurella multocida|''Pasteurella multocida'']] colonises and produces osteolytic toxin, leading to bone resorption

*Malformation of snout in growing pigs as well as poor growth  

*Malformation of snout in growing pigs as well as poor growth  

*increases with high stocking density and poor ventilation

*increases with high stocking density and poor ventilation

*In rapidly growing young pigs (4-12 weeks old)

*In rapidly growing young pigs (4-12 weeks old)

*Clinical signs

*Clinical signs

**Progressive facial deformity with [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]], catarrhal nasal discharge  

**Progressive facial deformity with [[Rhinitis#Infectious causes of rhinitis|rhinitis]], catarrhal nasal discharge  

**Sneezing, coughing, can progress to dyspnoea and anorexia

**Sneezing, coughing, can progress to dyspnoea and anorexia

*2 forms of the disease

*2 forms of the disease

**''''Progressive' atrophic rhinitis'''

**''''Progressive' atrophic rhinitis'''

***Due to infection of the nasal turbinates by P.multocida strains carrying the toxA gene that encodes for an osteolytic toxin. [[Pasteurella multocida|''P.multocida'']] adheres poorly to mucous membranes, and therefore requires a predisposing nasal insult to assist colonisation eg: co-infection with [[Bordetella bronchiseptica|''B.bronchiseptica'']] or [[Cytomegalovirus|Porcine cytomegalovirus (inclusion body rhinitis)]]

***Due to infection of the nasal turbinates by P.multocida strains carrying the toxA gene that encodes for an osteolytic toxin. [[Pasteurella multocida|''P.multocida'']] adheres poorly to mucous membranes, and therefore requires a predisposing nasal insult to assist colonisation eg: co-infection with [[Bordetella bronchiseptica|''B.bronchiseptica'']] or [[Porcine Cytomegalovirus|Porcine cytomegalovirus (inclusion body rhinitis)]]

***Turbinate bone atrophy is permanent and progressive

***Turbinate bone atrophy is permanent and progressive

**''''Non-progressive' atrophic rhinitis'''

**''''Non-progressive' atrophic rhinitis'''

***Turbinate bone can regenerate by the time of slaughter

***Turbinate bone can regenerate by the time of slaughter

*''[[Bordetella bronchiseptica]]'' also causes [[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|broncho]][[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|pneumonia]]

*''[[Bordetella bronchiseptica]]'' also causes [[Bronchitis#Infectious causes of bronchitis or bronchiolitis|broncho]][[Pneumonia Overview#Infectious causes of pneumonia|pneumonia]]

[[Category:Pig]]

[[Category:Respiratory Diseases - Pig]]

[[Category:To Do - Respiratory]][[Category:To Do - Major]]