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==Introduction==

==Introduction==

''A.suis'' is a beta-haemolytic '''Gram-negative bacterium'''.  Strains of ''A.Suis'' vary due to differences in their '''lipopolysaccharides (LPS)''', which is known as ''''O' antigens''' and are referred to as '''O1,O2''' and '''O3''' and '''capsules (CPS)''', called ''''K' antigen''' with variants described as '''K1, K2''' and '''K3'''. More than 95% of A. suis clinical isolates are cross-reactive with O1/K1 or O2/K3 antiserum and more severe infection were noted with O2/K2 srain <ref name="Slavic et al., 2000">Slavic, D., DeLay, J., Hayes, M.A., MacInnes, J.I.(2000) '''Comparative pathogenicity of different Actinobacillus suis O/K serotypes'''. ''Canadian Journal of Veterinary Research'', 64(2):81-87.</ref>.  This '''opportunistic''' bacteria causes  [[Actinobacillosis - Pig| '''actinobacillosis in pigs''']],  and has been linked to septicaemia, acute haemorrhagic pulmonary infarction and necrotizing pneumonia in horses, airsaculitis in waterfowl, neonatal calf pneumonia and localised infections and polyarthritis in alpacas. [[Actinobacillus equuli| horses]],[[Actinobacillosis - Cattle| cattle]] and can infect [[Actinobacillus suis#signalment| various other species.

''A.suis'' is a beta-haemolytic '''Gram-negative bacterium'''.  Strains of ''A.suis'' vary due to differences in their '''lipopolysaccharides (LPS)''', which are known as ''''O' antigens''' and are referred to as '''O1,O2''' and '''O3''' and '''capsules (CPS)''', refered to as''''K' antigen''' with variants described as '''K1, K2''' and '''K3'''. More than 95% of A. suis clinical isolates are cross-reactive with O1/K1 or O2/K3 antiserum and more severe infection were noted with O2/K2 srain <ref name="Slavic et al., 2000">Slavic, D., DeLay, J., Hayes, M.A., MacInnes, J.I.(2000) '''Comparative pathogenicity of different Actinobacillus suis O/K serotypes'''. ''Canadian Journal of Veterinary Research'', 64(2):81-87.</ref>.  This '''opportunistic''' bacteria causes  [[Actinobacillosis - Pig| '''actinobacillosis in pigs''']],  and has been linked to septicaemia, acute haemorrhagic pulmonary infarction and necrotizing pneumonia in horses, airsaculitis in waterfowl, neonatal calf pneumonia and localised infections and polyarthritis in alpacas. [[Actinobacillus equuli| horses]],[[Actinobacillosis - Cattle| cattle]] and can infect [[Actinobacillus suis#signalment| various other species.

''A.suis'' have genes that encode toxins similar to apxI and apxII of [[Actinobacillus pleuropneumoniae| ''A. pleuropneumoniae'']], but they are less virulent.  Once an animal is infected with ''A.suis'' it can provide partial '''cross protection against ''A. pleuropneumoniae'''''.  

''A.suis'' have genes that encode toxins similar to apxI and apxII of [[Actinobacillus pleuropneumoniae| ''A. pleuropneumoniae'']], but they are less virulent.  Once an animal is infected with ''A.suis'' it can provide partial '''cross protection against ''A. pleuropneumoniae'''''.