Difference between revisions of "Porcine Stress Syndrome"
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[[Category:Muscles - Developmental Pathology]] | [[Category:Muscles - Developmental Pathology]] | ||
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Revision as of 15:50, 1 July 2011
- Malignant hyperthermia
- Pigs, dogs, humans
- Possibly a cellular defect resulting in high intacellular calcium ion concentration
- -> Activates myofibrillar ATPase -> rapid intracellular glycolysis -> increase in body heat -> denature protein -> cell death -> leakage of cellular content -> oedema
- Grossly:
- Muscles are pale, soft and exudative
- Histologically:
- Segmental hypercontraction
- Monophasic, multifocal segmental necrosis
- Inherited
- Triggered by halothane anaesthesia, stress of handling, transportation or slaughter