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| − | {{VPU}}
| + | <gallery> |
| − | [[Image:High power.jpg|thumb|400px|left|High power micrograph of mass]]
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| − | [[Image:Gross Heart.jpg|thumb|200px|Gross heart with pericardium removed]][[Image:Liver pathology.jpg|thumb|200px|Masses in liver]][[Image:Low power.jpg|thumb|200px|Low power micrograph of mass]]
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| − | You are presented with a case of a 9 year old, male neutered golden retriever. The dog had a history of sudden death. On gross examination the pericardial sac was full of blood, a 4cm mass is present on the right atrium.
| + | Image:Gross Heart.jpg|<p>'''Pituitary Gland Low Power 1'''</P> |
| − | <br><br>
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| − | Multifocal to coalescing, dark red, pinpoint to 5cm masses were also present throughout the liver.
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| − | <br><br>
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| − | Microscopically, the mass is composed of multiple, variably-sized, irregular, blood-filled channels and spaces.
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| − | <br><br>
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| − | On high power, these spaces channels are lined by plump, pleomorphic spindle cells which exhibit marked anisocytosis and anisokaryosis. The nuclei contain 1-2 dark basophilic nucleoli. Within this single high power field (400x), four mitotic figures are present (arrows). The cells are not arranged in an organised manner, instead they are ‘piled up’ on top of one another.
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| − | <br><br> | |
| − | <WikiQuiz
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| − | questionnumber="1"
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| − | question="
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| − | Which of the following is the most likely diagnosis for this right atrial mass?
| + | Image:High power.jpg|<p>'''Pituitary Gland Low Power 2'''</P> |
| − | "
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| − | choice5="Haemangiosarcoma"
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| − | choice1="Dilated cardiomyopathy"
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| − | choice4="Haematoma"
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| − | choice2="Hypertrophic cardiomyopathy"
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| − | choice3="Chemodectoma"
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| − | correctchoice="5"
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| − | feedback5="'''Correct!''' Cellular pleomorphism, anisocytosis, anisokaryosis, high mitotic index and lack of tissue organisation are all histological features of malignancy. The spindle shape of the neoplastic cell population is indicative of a malignant mesenchymal tumour i.e. a sarcoma. The formation of blood-filled channels and spaces is typical of a tumour of endothelial cells, which under normal circumstances are responsible for lining the internal surface of blood vessels. The diagnosis in this case is therefore haemangiosarcoma. [[Haemangiosarcoma|WikiVet Article: Haemangiosarcoma]]
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| − | "
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| − | feedback1="'''Incorrect.''' Cellular pleomorphism, anisocytosis, anisokaryosis, high mitotic index and lack of tissue organisation are all histological features of malignancy. The spindle shape of the neoplastic cell population is indicative of a malignant mesenchymal tumour i.e. a sarcoma. The formation of blood-filled channels and spaces is typical of a tumour of endothelial cells, which under normal circumstances are responsible for lining the internal surface of blood vessels. The diagnosis in this case is therefore haemangiosarcoma.[[Haemangiosarcoma|WikiVet Article: Haemangiosarcoma]]
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| − | "
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| − | feedback4="'''Incorrect.''' Cellular pleomorphism, anisocytosis, anisokaryosis, high mitotic index and lack of tissue organisation are all histological features of malignancy. The spindle shape of the neoplastic cell population is indicative of a malignant mesenchymal tumour i.e. a sarcoma. The formation of blood-filled channels and spaces is typical of a tumour of endothelial cells, which under normal circumstances are responsible for lining the internal surface of blood vessels. The diagnosis in this case is therefore haemangiosarcoma. [[Haemangiosarcoma|WikiVet Article: Haemangiosarcoma]]
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| − | "
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| − | feedback2="'''Incorrect.''' Cellular pleomorphism, anisocytosis, anisokaryosis, high mitotic index and lack of tissue organisation are all histological features of malignancy. The spindle shape of the neoplastic cell population is indicative of a malignant mesenchymal tumour i.e. a sarcoma. The formation of blood-filled channels and spaces is typical of a tumour of endothelial cells, which under normal circumstances are responsible for lining the internal surface of blood vessels. The diagnosis in this case is therefore haemangiosarcoma. [[Haemangiosarcoma|WikiVet Article: Haemangiosarcoma]]
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| − | "
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| − | feedback3="'''Incorrect.''' Cellular pleomorphism, anisocytosis, anisokaryosis, high mitotic index and lack of tissue organisation are all histological features of malignancy. The spindle shape of the neoplastic cell population is indicative of a malignant mesenchymal tumour i.e. a sarcoma. The formation of blood-filled channels and spaces is typical of a tumour of endothelial cells, which under normal circumstances are responsible for lining the internal surface of blood vessels. The diagnosis in this case is therefore haemangiosarcoma.[[Haemangiosarcoma|WikiVet Article: Haemangiosarcoma]]
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| − | "
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| − | image= "File:Right atrium cropped.jpg">
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| − | </WikiQuiz> | |
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| | + | Image:Liver pathology.jpg|<p>'''Pars Distalis'''</P> |
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| | + | Image:Right atrium.jpg|<p>'''Pars Intermedia'''</P> |
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| | + | Image:Low power.jpg|<p>'''Pars Nervosa</P> |
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| − | {{Chris Palgrave reviewed
| + | Image:Haemangioma.jpg|<p>'''Pars Nervosa</P> |
| − | |date = 16th July 2011 | |
| − | }}
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| − | [[Category:R(D)SVS VPU]]
| + | </gallery> |
| − | [[Category:Chris Palgrave reviewed]]
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