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Category:Oral Cavity - Vesicular Pathology (view source)
Revision as of 13:07, 18 July 2011
, 13:07, 18 July 2011no edit summary
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====Pathology====
−=====Gross=====
−#Initially - hyperaemia of mucosa (e.g. catarrhal inflammation) then within 12 hours produces fluid filled vesicles on dorsum of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]], may be other places
−#Small vesicle coalesce to produce big ones -i.e. Bullae
−#Very quickly rupture; epithelium appears dirty grey in colour because of necrosis - sloughed skin, very good for diagnosis
−#Leave painful, hyperaemic epithelium
−#Looks like "ulcer "with ragged edge but not a true ulcer as stratum germinativum retained and will rapidly heal completely in about 2 weeks unless becomes secondarily infected
−=====Microscopic lesions=====
−*Degeneration of prickle cells
−*Cells "balloon" as fill with fluid and then die to produce vesicle containing straw coloured or clear fluid
*May produce vesicles in mouth that are indistinguishable from foot and mouth disease
−*Swine vesicular disease produces sporadic large outbreaks
−**Approximately 5% have lesions in mouth, foot lesions much more common
−*Vesicles in mouth are often caused by hot food - especially in dogs.
−*Can produce quite big vesicles, but will heal.
−*No major problems associated with vesicles on [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]] in dogs (except if due to drinking battery acid, but this also produces vomiting).
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===Pathology===
===Pathology===
*Damage to prickle cells (stratum spinosum).
*Damage to prickle cells (stratum spinosum).
−*Appears as accumulation of fluid within epithelium, quickly erodes leaving hyperaemic [[stratum germinativum]].
+*Appears as accumulation of fluid within epithelium, quickly erodes leaving hyperaemic stratum germinativum.
*Heals by proliferation of new cells, so long as infection does not continue.
*Heals by proliferation of new cells, so long as infection does not continue.
===Pathogenesis===
===Pathogenesis===
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#Ingestion of hot food (corrosive liquids)
#Ingestion of hot food (corrosive liquids)
#Systemic viral diseases. ''e.g'':
#Systemic viral diseases. ''e.g'':
−##[[Foot and Mouth Disease Virus|Foot and Mouth disease]] - ruminants and pigs
+##[[Foot and Mouth Disease|Foot and Mouth disease]] - ruminants and pigs
−##[[Vesicular stomatitis]] - horse, pigs, cattle
+##[[Vesicular Stomatitis Virus]] - horse, pigs, cattle
−##[[Vesicular exanthema]] - pigs
+##[[Vesicular Exanthema - Pig|Vesicular Exanthema]] - pigs
N.B. All are indistinguishable from FMD clinically.
N.B. All are indistinguishable from FMD clinically.
−===[[Foot and Mouth Disease (FMDV)]]===
+===[[Foot and Mouth Disease|Foot and Mouth Disease (FMDV)]]===
−===[[Swine Vesicular Disease]]===
===[[Swine Vesicular Disease]]===
−===Vesicles in dogs===
+===[[Oral Vesicles in Dogs]]===
−