Difference between revisions of "Actinobacillus species"
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| − | # | + | <big><center>[[Infectious agents and parasites|'''BACK TO INFECTIOUS AGENTS AND PARASITES''']]</center></big> |
| + | <big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big> | ||
| + | |||
| + | * Cause [[Peritoneal cavity - inflammatory#In horses|peritonitis in horses]] | ||
| + | * ''A. pleuropneumoniae'' causes [[Bacterial infections#Actinobacillus pleuropneumoniae|pneumonia]] in pigs | ||
| + | * Cause [[General Pathology - Chronic Inflammation#Granulomatous Inflammation|granulomatous inflammation]]. | ||
| + | ** E.g. ''Actinobacillus lignieresii'' causes wooden tongue in cattle -> [[Muscles - inflammatory#Wooden tongue|myositis]] | ||
| + | *''A. equuli'' in [[Joints - inflammatory#In Horses|arthritis of horses]] | ||
| + | |||
| + | ===Overview=== | ||
| + | |||
| + | |||
| + | ===''Actinobacillus'' characteristics=== | ||
| + | |||
| + | *Small Gram negative coccobacilli | ||
| + | *Oxidase negative | ||
| + | *Do not grow on MacConkey | ||
| + | |||
| + | |||
| + | ===''Actinobacillus lignieresii''=== | ||
| + | |||
| + | *Commensal in the mouth of sheep and cattle | ||
| + | *Penetrates damaged mucosa to cause a granuloma, a condition known as Actinobacillosis | ||
| + | *Enodogenous, sporadic and chronic infection | ||
| + | *Lesions in the tongue, cheek, lips and sometimes in the lower gut and lungs from aspiration | ||
| + | *Often spreads from the site of infection to lymphatics | ||
| + | *Formation of fibrous tissue in the lesions lead to hardening of the tissue, hence the condition is known as 'wooden tongue' in cattle | ||
| + | *In sheep abscesses with thick walls are produced | ||
| + | *Feeding is impaired, causing loss of condition | ||
| + | *Recovery with antibiotics | ||
| + | |||
| + | |||
| + | ===''Actinobacillus equuli''=== | ||
| + | |||
| + | *Commensal of the equine intestinal mucosa | ||
| + | *Infection at birth causes severe enteritis and septicaemia within 24 hours, known as sleepy foal disease | ||
| + | *In foals that survive neonatal infection the condition progresses to cause joint infections and purulent nephritis | ||
| + | *RTX group cytotoxin present | ||
| + | |||
| + | |||
| + | ===''Actinobacillus suis''=== | ||
| + | |||
| + | *Fatal septicaemia in pigs 1-8 weeks old | ||
| + | *Causes abscesses in joints and lungs of older pigs | ||
| + | *Carried in the nasopharynx of pigs and nose of horses | ||
| + | *Carriage may confer immunity to the more severe pleuropneumonia | ||
| + | |||
| + | |||
| + | ===''Actinobacillus pleuropneumoniae''=== | ||
| + | |||
| + | *Contagious porcine pleuropneumonia | ||
| + | *Endemic in UK | ||
| + | *Most strains are NAD-dependent (grow on Heated Blood agar) | ||
| + | *Positive CAMP reaction | ||
| + | *12 serotypes causing the same disease | ||
| + | *Different serotypes in different regions, with serotypes 3,6 and 8 the most common in the UK | ||
| + | *Acute disease in susceptible herds with high morbidity and mortality | ||
| + | *Carrier herds have some immunity, protecting from acute disease, where lesions are often subclinical, and deaths sporadic | ||
| + | *Lung scarring and pleural adhesions in many recovered animals | ||
| + | *Solid immunity develops in recovered animals to all serotypes | ||
Revision as of 18:02, 17 December 2007
- Cause peritonitis in horses
- A. pleuropneumoniae causes pneumonia in pigs
- Cause granulomatous inflammation.
- E.g. Actinobacillus lignieresii causes wooden tongue in cattle -> myositis
- A. equuli in arthritis of horses
Overview
Actinobacillus characteristics
- Small Gram negative coccobacilli
- Oxidase negative
- Do not grow on MacConkey
Actinobacillus lignieresii
- Commensal in the mouth of sheep and cattle
- Penetrates damaged mucosa to cause a granuloma, a condition known as Actinobacillosis
- Enodogenous, sporadic and chronic infection
- Lesions in the tongue, cheek, lips and sometimes in the lower gut and lungs from aspiration
- Often spreads from the site of infection to lymphatics
- Formation of fibrous tissue in the lesions lead to hardening of the tissue, hence the condition is known as 'wooden tongue' in cattle
- In sheep abscesses with thick walls are produced
- Feeding is impaired, causing loss of condition
- Recovery with antibiotics
Actinobacillus equuli
- Commensal of the equine intestinal mucosa
- Infection at birth causes severe enteritis and septicaemia within 24 hours, known as sleepy foal disease
- In foals that survive neonatal infection the condition progresses to cause joint infections and purulent nephritis
- RTX group cytotoxin present
Actinobacillus suis
- Fatal septicaemia in pigs 1-8 weeks old
- Causes abscesses in joints and lungs of older pigs
- Carried in the nasopharynx of pigs and nose of horses
- Carriage may confer immunity to the more severe pleuropneumonia
Actinobacillus pleuropneumoniae
- Contagious porcine pleuropneumonia
- Endemic in UK
- Most strains are NAD-dependent (grow on Heated Blood agar)
- Positive CAMP reaction
- 12 serotypes causing the same disease
- Different serotypes in different regions, with serotypes 3,6 and 8 the most common in the UK
- Acute disease in susceptible herds with high morbidity and mortality
- Carrier herds have some immunity, protecting from acute disease, where lesions are often subclinical, and deaths sporadic
- Lung scarring and pleural adhesions in many recovered animals
- Solid immunity develops in recovered animals to all serotypes