Changes

===Activin===

===Activin===

Activin is a glycoprotein that is produced within granulosa cells in females and sertoli cells in the male. Activin is thought to play an almost directly opposite role to that of inhibin and is involved in many physiological functions including stimulation of FSH synthesis and secretion and other roles including cell proliferation, cell differentiation, apoptosis and homeostasis.

Activin is a glycoprotein that is produced within granulosa cells in females and sertoli cells in the male. Activin is thought to play an almost directly opposite role to that of inhibin and is involved in many physiological functions including stimulation of FSH synthesis and secretion and other roles including cell proliferation, cell differentiation, apoptosis and homeostasis.

 

The target tissue for activiin in the male is the epididymis whilst in the female it is the anterior pituitary gland, specifically gonadotroph cells. In males and females activin stimulates FSH secretion.

The target tissue for activin in the male is the epididymis where it enhances spermatogenesis via increased FSH secretion. Activin also enhances the effect of LH on the testes.

In the female activin has an effect on the anterior pituitary gland, specifically on gonadotroph cells resulting in increased FSH secretion. The increased concentrations of activin results in increased FSH binding on the female follicle and FSH-induced aromatisation (increased synthesis of oestrogens). Activin also enhances the action of LH in the ovary.

A further non-reproductive role of activin is it's role in skin lesions where it is thought to stimulate keratinocytes.

===Prostaglandin F2α===

===Prostaglandin F2α===