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Pigmentation - Pathology (view source)
Revision as of 22:01, 27 October 2011
, 22:01, 27 October 2011→Ceroid
==Exogenous Pigmentation==
==Exogenous Pigmentation==
* Black or grey speckles in lungs.
* Black or grey speckles in lungs.
====Histological Apprearance====
====Histological Appearance====
* Black extra- or intra-cellular granules .
* Black extra- or intra-cellular granules .
*** Yolks of eggs.
*** Yolks of eggs.
*** Fat of horses and Channel Island cattle.
*** Fat of horses and Channel Island cattle.
* May be confused with a [[Pigmentation and Calcification - Pathology#Jaundice|jaundiced]] liver or subcutis.
* May be confused with a [[Icterus|jaundiced]] liver or subcutis.
** Adding minced tissue to a mixture of ether and water can distinguish the two.
** Adding minced tissue to a mixture of ether and water can distinguish the two.
*** Carotenoids are fat-soluble and dissolve in the ether fraction.
*** Carotenoids are fat-soluble and dissolve in the ether fraction.
** For example, in wound healing.
** For example, in wound healing.
*** [[Healing and Repair - Pathology#Scarring|Scars]] are pigmented.
*** [[Healing and Repair - Pathology#Scarring|Scars]] are pigmented.
* Hyperpigmentation may be significant in excess cortisol states such as [[Adrenal Glands - Pathology#Adrenal Hyperfunction|Cushing’s Disease]].
* Hyperpigmentation may be significant in excess cortisol states such as [[Hyperadrenocorticism|Cushing’s Disease]].
** There may be tumours of melanocytes.
** There may be tumours of melanocytes.
* Albinos have no pigment in their hair or skin, and have pink irises.
* Albinos have no pigment in their hair or skin, and have pink irises.
* Found in [[Macrophages|macrophages]] of [[Bone Marrow - Anatomy & Physiology|bone marrow]], [[Liver - Anatomy & Physiology|liver]], lungs, and [[Lymph Nodes - Anatomy & Physiology|lymph nodes]].
* Found in [[Macrophages|macrophages]] of [[Bone Marrow - Anatomy & Physiology|bone marrow]], [[Liver - Anatomy & Physiology|liver]], lungs, and [[Lymph Nodes - Anatomy & Physiology|lymph nodes]].
=====Photosensitisation=====
=====[[Photosensitisation]]=====
* Porphyrin is a fluorescent pigment.
* Porphyrin is a fluorescent pigment.
* Lipofuscin is the ageing pigment.
* Lipofuscin is the ageing pigment.
** Can be seen in senile animals in
** Can be seen in senile animals in
*** [[Muscles Degenerative - Pathology#Pigmentation|Muscle]]
*** [[Muscle Pigmentation|Muscle]]
**** E.g. in "[[Disorders of Cell Growth - Pathology#Brown Atrophy|brown atrophy]]".
**** E.g. in "[[Cell Growth Disorders#Brown Atrophy|brown atrophy]]".
*** Myocardium
*** Myocardium
*** Neurones (particularly those of horses)
*** Neurones (particularly those of horses)
** A variety of tissues including fat, cardiac muscle, splenic trabeculae and intestine in Vitamin E deficiency.
** A variety of tissues including fat, cardiac muscle, splenic trabeculae and intestine in Vitamin E deficiency.
*** Sometimes being so prominent as to be grossly visible.
*** Sometimes being so prominent as to be grossly visible.
**** Yellow fat disease
**** [[Steatitis|Yellow fat disease]]
***** Pigs and cats
***** Pigs and cats
**** Brown gut
**** Brown gut
***** Dogs
***** Dogs
Also see [[Liver Pigmentation]].
[[Category:General Pathology]]
[[Category:General Pathology]]