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| + | #redirect[[Gout - Reptiles]] |
| − | [[Image:Bump2.jpg|200px|thumb|right|'''Biopsy of this swelling revealed renal gout''' © RVC]] | |
| − | ==Introduction==
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| − | Gout is a metabolic disease where there is a precipitation of urate crystals in tissue. There are two types of gout in animals. | |
| − | *In primary gout there is an overproduction of [[Uric acid|uric acid]] related to an innate metabolic problem.
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| − | *In secondary gout, acquired disease interferes with the [[Uric acid|uric acid]] metabolism. Terrestrial reptiles are predisposed to secondary gout since nitrogenous waste is excreted as [[Uric acid|uric acid]].
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| − | In snakes, kidney disease often leads to the development of a visceral gout where uric acid crystals (tophi) are deposited in subcutaneous and internal tissues.
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| − | '''For more information on excretion, see''' [[Lizard and Snake Excretion]].
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| − | ==Examination==
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| − | History may show poor husbandry including limited access to water. Snakes often present as anorexic and lethargic. Often if kidney disease is involved there is a palpable lump in the caudal third.
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| − | For a differential diagnosis list of other causes of lumps in the body, see [[Snake Lumps and Bumps]].
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| − | [[Image:Necropsy_copy.jpg|200px|thumb|right|'''Tophi in renal tissue''' - © RVC]]
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| − | ==Diagnosis==
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| − | The diagnosis of gout may be suspected on history and physical examination. [[Lizard and Snake Biochemistry|Biochemistry]] may indicate a [[Lizard_and_Snake_Biochemistry#Hyperuricaemia|hyperuricaemia]]. Sometimes [[Lizard and Snake Imaging|radiography]] is useful if calcium is deposited with the urate crystals. Biopsy of any lumps may be useful. A definite diagnosis is the demonstration of tophi in diseased tissue.
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| − | '''For more information on physical examinations, see''' [[Snake Physical Examination]].
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| − | '''For more information on biopsy collection, see''' [[Lizard and Snake Specimen Collection and Evaluation|Specimen Collection and Evaluation]].
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| − | [[Image:Renal_gout_python_regius.jpg|200px|thumb|right|'''Tophi in diseased tissue''' © RVC]]
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| − | ==Therapy==
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| − | Supportive treatment especially aimed at rehydration may be useful but gout carries a poor prognosis. Previously allopurinol (a xanthine oxidase inhibitor that decreases formation of uric acid) has been recommended as a treatment of hyperuricaemia in reptiles and birds but in fact appears to be of little use. Other drugs such as uricases (enzymes involved in the degradation of uric acid to allantoin) may be more useful.
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| − | '''For more information, see''' [[Snake Supportive Care]].
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| − | ==Prevention==
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| − | Any bouts of dehydration will predispose to the development of gout so good husbandry is important in prevention. Veterinarians should ensure adequate hydration of reptiles prior to any drug therapy especially the use of nephrotoxic drugs.
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| − | '''For more information on good husbandry practices, see''' [[:Category: Snake Husbandry| Snake Husbandry]].
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| − | [[Category:Snake_Diseases]]
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