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'''Autoimmune disease''' is defined as ''a disease state characterised by a specific antibody or cell mediated response against the body's own tissues ('self' antigens).

'''Autoimmune disease''' is defined as ''a disease state characterised by a specific antibody or cell mediated response against the body's own tissues ('self' antigens).

The breakdown of [[Immune Tolerance - WikiBlood|tolerance]] to self antigens and the failure to regulate pathological immune responses are both responsible for autoimmune diseases. It has been shown in mice that thymectomy causes autoimmune disease, and plays a very important role in the recognition of 'self'.  

The breakdown of [[Immune Tolerance|tolerance]] to self antigens and the failure to regulate pathological immune responses are both responsible for autoimmune diseases. It has been shown in mice that thymectomy causes autoimmune disease, and plays a very important role in the recognition of 'self'.  

Particular individuals may be more susceptible to autoimmune diseases due to:

Particular individuals may be more susceptible to autoimmune diseases due to:

!width="200"|Cell mediated

!width="200"|Cell mediated

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| '''Type of hypersensitivity''' || [[Type II Hypersensitivity - WikiBlood|Type II]] || [[Type III Hypersensitivity - WikiBlood|Type III]] || [[Type IV Hypersensitivity - WikiBlood|Type IV]]  

| '''Type of hypersensitivity''' || [[Type II Hypersensitivity|Type II]] || [[Type III Hypersensitivity|Type III]] || [[Type IV Hypersensitivity|Type IV]]  

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| '''Pathogenesis''' || Antibody to cell surface or matrix antigens  || Antibody to soluble self antigens || T cell and macrophage activation to self antigens

| '''Pathogenesis''' || Antibody to cell surface or matrix antigens  || Antibody to soluble self antigens || T cell and macrophage activation to self antigens

|  || [[Myasthenia Gravis|Myasthenia gravis]]  ||  || [[Hypothyroidism]] (lymphocytic throiditis)

|  || [[Myasthenia Gravis|Myasthenia gravis]]  ||  || [[Hypothyroidism]] (lymphocytic throiditis)

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|  || [[Pemphigus Vulgaris]]  ||  || [[Hypoadrenocorticism]] (Addisons disease)

|  || [[Pemphigus]]  ||  || [[Hypoadrenocorticism]] (Addisons disease)

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|  || [[Bullous Pemphigoid]]  ||  ||

|  || [[Bullous Pemphigoid]]  ||  ||

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[[Category:Autoimmune Diseases]]

[[Category:Autoimmune Diseases]]