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==Aplasia==
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Aplasia also known as agenesis is the complete failure of an organ or part to form during embryogenesis.
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Examples
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<ul>
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<li>inherited genetic defects</li>
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<li>absence of limbs or amelia</li>
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</ul>
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==Atrophy==
 
==Atrophy==
 
Atrophy is a decrease in the size of the cells and organ, occurring after the organ has reached normal size.
 
Atrophy is a decrease in the size of the cells and organ, occurring after the organ has reached normal size.
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* A senile change in muscles where they appear brownish rather than reddish in colour.  
 
* A senile change in muscles where they appear brownish rather than reddish in colour.  
* Due to the intracytoplasmic accumulation of [[Pigmentation and Calcification - Pathology#Lipofuscin|lipofuscin]] within the muscle fibres.
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* Due to the intracytoplasmic accumulation of [[Pigmentation - Pathology#Lipofuscin|lipofuscin]] within the muscle fibres.
 
** The "wear and tear" pigment.
 
** The "wear and tear" pigment.
  
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