Feline Infectious Anaemia: Difference between revisions

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==Pathogenesis==

The pathogenesis of Mhf is not fully understood. It is thought that the presence of the parasite on the surface of the erythrocytes may induce [[Immunoglobulins_-_Overview|antibody production]]<ref name="Hagiwara"></ref>, resulting in[[Regenerative_and_Non-Regenerative_Anaemias#Haemolysis|haemolysis]] which is primarily extravascular. The haemolysis may be due to direct damage of erythrocytes by the organism or as a result of the antibodies produced by the infected animal <ref name="Wardrop"></ref>.

The pathogenesis of Mhf is not fully understood. It is thought that the presence of the parasite on the surface of the erythrocytes may induce [[Immunoglobulins_-_Overview|antibody production]]<ref name="Hagiwara"></ref>, resulting in [[Regenerative_and_Non-Regenerative_Anaemias#Haemolysis|haemolysis]] which is primarily extravascular. The haemolysis may be due to direct damage of erythrocytes by the organism or as a result of the antibodies produced by the infected animal <ref name="Wardrop"></ref>.

Cats can produce an immune response which results in the disappearance of organisms from the blood. Production of uninfected erythrocytes can then result in an increase in haematocrit.

Cats can produce an immune response which results in the disappearance of organisms from the blood. Production of uninfected erythrocytes can then result in an increase in [[haematocrit]].

It is thought that recovered cats can become subclinical carriers, with the potential for the disease to recrudesce if the animal is in a stressed state eg pregnancy, illness<ref name = "Harvey">Harvey JW and Gaskin JM (1978)Feline haemobartonellosis;attempts to induce relapses of clinical disease in chronically infected cats.'''J Am Anim Hosp Assoc'''14:453</ref>

It is thought that recovered cats can become subclinical carriers, with the potential for the disease to recrudesce if the animal is in a stressed state eg pregnancy, illness.<ref name = "Harvey">Harvey JW and Gaskin JM (1978)Feline haemobartonellosis;attempts to induce relapses of clinical disease in chronically infected cats.'''J Am Anim Hosp Assoc'''14:453</ref>

==Clinical signs==

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 ==Pathogenesis==
-The pathogenesis of Mhf is not fully understood. It is thought that the presence of the parasite on the surface of the erythrocytes may induce [[Immunoglobulins_-_Overview|antibody production]]<ref name="Hagiwara"></ref>, resulting in[[Regenerative_and_Non-Regenerative_Anaemias#Haemolysis|haemolysis]] which is primarily extravascular. The haemolysis may be due to direct damage of erythrocytes by the organism or as a result of the antibodies produced by the infected animal <ref name="Wardrop"></ref>.
+The pathogenesis of Mhf is not fully understood. It is thought that the presence of the parasite on the surface of the erythrocytes may induce [[Immunoglobulins_-_Overview|antibody production]]<ref name="Hagiwara"></ref>, resulting in [[Regenerative_and_Non-Regenerative_Anaemias#Haemolysis|haemolysis]] which is primarily extravascular. The haemolysis may be due to direct damage of erythrocytes by the organism or as a result of the antibodies produced by the infected animal <ref name="Wardrop"></ref>.
-Cats can produce an immune response which results in the disappearance of organisms from the blood. Production of uninfected erythrocytes   can then result in an increase in haematocrit.
+Cats can produce an immune response which results in the disappearance of organisms from the blood. Production of uninfected erythrocytes can then result in an increase in [[haematocrit]].
-It is thought that recovered cats can become subclinical carriers, with the potential for the disease to recrudesce if the animal is in a stressed state eg pregnancy, illness<ref name = "Harvey">Harvey JW and Gaskin JM (1978)Feline haemobartonellosis;attempts to induce relapses of clinical disease in chronically infected cats.'''J Am Anim Hosp Assoc'''14:453</ref>
+It is thought that recovered cats can become subclinical carriers, with the potential for the disease to recrudesce if the animal is in a stressed state eg pregnancy, illness.<ref name = "Harvey">Harvey JW and Gaskin JM (1978)Feline haemobartonellosis;attempts to induce relapses of clinical disease in chronically infected cats.'''J Am Anim Hosp Assoc'''14:453</ref>
 ==Clinical signs==