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==Humoral==
 
==Humoral==
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While cell-mediated immunity is important in tissue infections, such as Leishmania, specific antibodies are important in controlling parasites that live in the bloodstream, e.g. malaria. Mechanisms of antibody-mediated immunity include:
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*Directly damaging protozoa
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*Activating [[Complement|complement]], and the subsequent Membrane Attack Complex
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*Blocking attachment to host cells
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*Enhancing macrophage phagocytosis
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*Involvement in antibody-dependent cell-mediated cytotoxicity
 
The humoral response involves the production of [[Immunoglobulin E|IgE]]. It is stimulated by [[Mast Cells|mast cells]] producing IL-4 ([[Innate Immune System|innate response]]). It also includes isotype switching of [[Lymphocytes#B Cells|B cells]] to produce [[Immunoglobulin E|IgE]].
 
The humoral response involves the production of [[Immunoglobulin E|IgE]]. It is stimulated by [[Mast Cells|mast cells]] producing IL-4 ([[Innate Immune System|innate response]]). It also includes isotype switching of [[Lymphocytes#B Cells|B cells]] to produce [[Immunoglobulin E|IgE]].
  
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