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→Complement Fixation Pathways
===Complement Fixation Pathways===
===Complement Fixation Pathways===
<FlashCard questions="10">
<FlashCard questions="10">
*Alternative
*Alternative
*Mannose-binding Lectin
*Mannose-binding Lectin
|l1=Complement - WikiBlood#Compelment Fixation Pathways
|l1=Complement#Compelment Fixation Pathways
|q2=Which immunoglobulins can activate the classical pathway?
|q2=Which immunoglobulins can activate the classical pathway?
|a2=
|a2=
*IgM
*IgM
*IgG
*IgG
|l2=Complement - WikiBlood#Compelment Fixation Pathways
|l2=Complement#Compelment Fixation Pathways
|q3=What are the components of the C1 complex
|q3=What are the components of the C1 complex
|a3=
|a3=
*C1r
*C1r
*C1s
*C1s
|l3=Complement - WikiBlood#Compelment Fixation Pathways
|l3=Complement#Compelment Fixation Pathways
|q4=Which two complexes bind to make the enzyme C3 convertase?
|q4=Which two complexes bind to make the enzyme C3 convertase?
|a4=
|a4=
*C2b
*C2a
*C4b
*C4b
|l4=Complement - WikiBlood#Compelment Fixation Pathways
|l4=Complement#Compelment Fixation Pathways
|q5=What initiates the membrane attack complex (MAC)?
|q5=What initiates the membrane attack complex (MAC)?
|a5=C3b
|a5=C3b
|l5=Complement - WikiBlood#Compelment Fixation Pathways
|l5=Complement#Compelment Fixation Pathways
|q6=What functions do the Ca fragments have?
|q6=What functions do the C fragments C3a, C4a, C5a and C2b have?
|a6=
|a6=
*Chemotactic for neutrophils
*Chemotactic for neutrophils
*Increases vascular permeability
*Increases vascular permeability
*Causes mast cell and basophil degranulation
*Causes mast cell and basophil degranulation
|l6=Complement - WikiBlood#Compelment Fixation Pathways
|l6=Complement#Compelment Fixation Pathways
|q7=What are efficient activators of the alternative pathway?
|q7=What are efficient activators of the alternative pathway?
|a7=
|a7=
*Yeasts
*Yeasts
*Fungi
*Fungi
|l7=Complement - WikiBlood#Alternative Pathway
|l7=Complement#Alternative Pathway
|q8=What are the main functions of the alternative pathway?
|q8=What are the main functions of the alternative pathway?
|a8=
|a8=
*To coat bacteria with iC3b
*To coat bacteria with iC3b
*To induce an acute inflammatory response
*To induce an acute inflammatory response
|l8=Complement - WikiBlood#Alternative Pathway
|l8=Complement#Alternative Pathway
|q9=What are lectins?
|q9=What are lectins?
|a9=Proteins which bind carbohydrates
|a9=Proteins which bind carbohydrates
|l9=Complement - WikiBlood#MB-Lectin Pathway
|l9=Complement#MB-Lectin Pathway
|q10=What does MASP stand for?
|q10=What does MASP stand for?
|a10=Mannose-binding lectin associated proteases
|a10=Mannose-binding lectin associated proteases
|l10=Complement - WikiBlood#MB-Lectin Pathway
|l10=Complement#MB-Lectin Pathway
</FlashCard>
</FlashCard>
===Complement Inhibitors===
===Complement Inhibitors===
<FlashCard questions="4">
<FlashCard questions="4">
*Delay acclerating factor (DAF)
*Delay acclerating factor (DAF)
**Increases the degredation of C1 esterase
**Increases the degredation of C1 esterase
|l1=Complement - WikiBlood#Complement Inhibitors
|l1=Complement#Complement Inhibitors
|q2=What do factors I and H do?
|q2=What do factors I and H do?
|a2=
|a2=
*Controls positive feedback by inhibiting C3b¯Bb
*Controls positive feedback by inhibiting C3b¯Bb
*Prevents the complement cascade from running to exhaustion every time it is activated
*Prevents the complement cascade from running to exhaustion every time it is activated
|l2=Complement - WikiBlood#Complement Inhibitors
|l2=Complement#Complement Inhibitors
|q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis?
|q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis?
|a3=Complement receptor 1 (CR1)
|a3=Complement receptor 1 (CR1)
|l3=Complement - WikiBlood#Complement Inhibitors
|l3=Complement#Complement Inhibitors
|q4=What does CD59 do?
|q4=What does CD59 do?
|a4=
|a4=
*Prevents cell lysis and pore formation
*Prevents cell lysis and pore formation
*It is a protective mechanism for cells
*It is a protective mechanism for cells
|l4=Complement - WikiBlood#Complement Inhibitors
|l4=Complement#Complement Inhibitors
</FlashCard>
</FlashCard>
===Functions of the Complement Cascade===
===Functions of the Complement Cascade===
*iC3b acts as a target for phagocytosis
*iC3b acts as a target for phagocytosis
*Phagocytes bind with the complement fragments destroying the bacteria
*Phagocytes bind with the complement fragments destroying the bacteria
|l1=Complement - WikiBlood#Functions
|l1=Complement#Functions
|q2=What role do complement fragments have to promote inflammation?
|q2=What role do complement fragments have to promote inflammation?
|a2=
|a2=
*Smaller complement fragments attract granulocytes to the site of inflammation
*Smaller complement fragments attract granulocytes to the site of inflammation
*Smaller complement fragments stimulate the degranulation of granulocytes
*Smaller complement fragments stimulate the degranulation of granulocytes
|l2=Complement - WikiBlood#Functions
|l2=Complement#Functions
|q3=By which process can C5-C9 directly kill pathogens?
|q3=By which process can C5-C9 directly kill pathogens?
|a3=Cell lysis
|a3=Cell lysis
|l3=Complement - WikiBlood#Functions
|l3=Complement#Functions
</FlashCard>
</FlashCard>
<br><br>
{{Jim Bee 2007}}
[[Category:Immunology Flashcards]]