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#redirect[[Reproductive Hormones Overview - Anatomy & Physiology]]
 
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|backcolour = FAFAD2
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|linkpage =Endocrine System - Pathology
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|linktext =Endocrine System
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|maplink = Endocrine System (Content Map) - Pathology
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|pagetype =Pathology
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Sex hormones are produced by the zona reticularis of the adrenal glands in addition to those produced by the ovary and testis:
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*'''Testis''': Produces '''androgens''':
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**Increase mitoses in skin.
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**Increase sebaceous secrretion.
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**Increase hair growth.
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*'''Ovary''': Produces '''oestrogens''' and '''progesterone'''.  Effects of oestrogens include:
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**Decreased collagen production.
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**Decreased sebaceous secretion.
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**Decreased epidermal thickness.
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**Decreased hair growth.
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**Increased skin pigmentation.
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==Hyperoestrogenism==
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===Females===
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'''''Ovarian Imbalance Type 1'''''
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Seen in adult bitches who present with alopecia and increased pigmentation round the perianal, perigenital and axillary areas. 
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Caused by:
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*Cystic ovaries.
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*Ovarian neoplasia.
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===Males===
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Dogs present with bilaterally symmetric alopecia, similar hyperpigmentation to that seen with female dogs with ovarian imbalance, loss of libido and gynaecomastia.  The dogs become attractive to other male dogs.
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Caused by:
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*[[Sertoli Cell Tumour - Pathology|Sertoli cell tumour]].
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*[[Male Feminising Syndrome - Pathology|Male feminising syndrome]].
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==Hyperandrogenism==
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===Females===
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'''''Ovarian Imbalance Type 2'''''
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Seen in young bitches spayed early.  Develop alopecia of perineum, ventral neck, chest and abdomen.  Bitch will have immature nipples and vulva and may diplay incontinence.
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''Treatment'':
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May respond to small doses of oestrogens.
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===Males===
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*Perianal gland hyperplasia.
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*Tail gland hyperplasia.
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*Seborrhoea.
 
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