Changes

==Overview==

==Overview==

[[Image:LH IgG.png|thumb|250px|right|'''IgG''']]

[[Image:LH IgG.png|thumb|250px|right|'''IgG''']]

''Shortened to IgG''

''Shortened to IgG''

IgG is the major antibody in blood plasma, and constitutes at least 80% of all antibodies in the body. It is the smallest immunoglobulin, so can readily leave the blood plasma and enter tissues.

IgG is the major antibody in blood plasma, and constitutes at least 80% of all antibodies in the body. It is the smallest immunoglobulin, so can readily leave the blood plasma and enter tissues. They can also cross the placenta, providing adaptive immunity to the foetus when the mother is under attack. IgG is also present in breast milk.

==Structure==

==Structure==

'''Dogs, rodents and cats'''

'''Dogs, rodents and cats'''

Have four subclasses. Dogs: G1-G4; Rodents: G1-G3 (G2a, G2b). Cats are unknown.

Have four subclasses. Dogs: G1-G4; Rodents: G1, G2a, G2b, G3. Cats are unknown.

'''Pigs'''

'''Pigs'''

==Production==

==Production==

IgG is produced by plasma cells in the spleen, bone marrow and lymph nodes.

IgG is produced by [[B cell differentiation|plasma cells]] in the spleen, bone marrow and lymph nodes.

==Function==

==Function==

Some IgG subclasses can activate complement via the classical pathway. Some subclasses act as targets for macrophages, eosinophils and [[Neutrophils|neutrophils]]. It is therefore the major antibody in tissue fluids and lymph. IgG specifically binds to antigens on bacteria, causing agglutination and opsonisation.

Some IgG subclasses can activate complement via the classical pathway. Some subclasses act as targets for [[Macrophages|macrophages]], [[Eosinophils|eosinophils]] and [[Neutrophils|neutrophils]]. It is therefore the major antibody in tissue fluids and lymph. IgG specifically binds to antigens on bacteria, causing agglutination and opsonisation.

==Links==

==Links==

[[Immunoglobulin M|Immunoglobulin M]]

[[Immunoglobulin M|Immunoglobulin M]]

[[Category:Immunoglobulins]]

[[Category:Immunoglobulins]]

[[Category:Image Review]]

[[Category:A&P Done]]

[[Category:To Do - AimeeHicks]]