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Corpus Luteum Regression - Anatomy & Physiology (view source)
Revision as of 18:09, 3 July 2012
, 18:09, 3 July 2012no edit summary
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== The Luteolytic Mechanism ==
* Prostaglandin F2α (PGF2α)
* Prostaglandin F2α (PGF2α)
* PGF2α secretion by the endometrium is almost non-existant during the first half of the luteal phase.
* PGF2α secretion by the endometrium is almost non-existant during the first half of the luteal phase.
* During the late luteal phase, pulses of PGF2α secretion increase in frequency and amplitude as the end of the luteal phase approaches.
* During the late luteal phase, pulses of PGF2α secretion increase in frequency and amplitude as the end of the luteal phase approaches.
* A critical number of
* A critical number of PGF2α pulses are required within a given time span to induce complete luteolysis.
** In the ewe, this is ~5 pulses in 24 hours.
* During the first half of the cycle, progesterone prevents the secretion of PGF2α by blocking the formation of oxytocin receptors on the uterus.
* Oxytocin and PGF2α stimulate each other in a positive feedback manner.
* The greater the number of endometrial oxytocin receptors, the greater the ability of oxytocin to stimulate PGF2α synthesis.
[[Category:Female Reproduction]]
[[Category:Bullet Points]]