Changes

===Cats===

===Cats===

* Paracetamol (acetominophen) - cats have a low level of N-acetyltransferase enzymes, which prevents them from metabolising the drug to non-toxic substances as humans do.  (ref name="ACVIM"> McConkey SE , Cribb A . The molecular mechanism of acetaminophen in dogs and cats. In: Proceedings of the 26th Annual American College of Veterinary Internal Medicine Meeting 2008, pp. 610 – 612 </ref>.They are also relatively deficient in methaemoglobin reductase and methaemoglobinaemia is also a feature of paracetamol toxicity in cats.  

* Paracetamol (acetominophen) - cats have a low level of N-acetyltransferase enzymes, which prevents them from metabolising the drug to non-toxic substances as humans do.  (ref name="ACVIM"> McConkey SE , Cribb A . The molecular mechanism of acetaminophen in dogs and cats. In: Proceedings of the 26th Annual American College of Veterinary Internal Medicine Meeting 2008, pp. 610 – 612 </ref>. They are also relatively deficient in methaemoglobin reductase and methaemoglobinaemia is also a feature of paracetamol toxicity in cats.  

* Diabetes mellitus - there is increased production of radicals resulting from various disease-induced metabolic compromises. Ketoacidotic cats have significantly higher numbers of Heinz bodies than non-ketoacidotic patients. (<ref name="DM"> Christopher M, Broussard J, Peterson M., (1995). '''Heinz body formation

* Diabetes mellitus - there is increased production of radicals resulting from various disease-induced metabolic compromises. Ketoacidotic cats have significantly higher numbers of Heinz bodies than non-ketoacidotic patients. (<ref name="DM"> Christopher M, Broussard J, Peterson M., (1995). '''Heinz body formation

associated with ketoacidosis in diabetic cats''' . J Vet Intern Med, Vol 9: p. 24 – 31.</ref>

associated with ketoacidosis in diabetic cats'''.J Vet Intern Med, Vol 9: p. 24 – 31.</ref>

 

* Hyperthyroidism - one study found increased numbers of Heinz bodies in hyperthyroid cats but patients were not significantly anaemic. (<ref name="Christopher"> Christopher M, (1989). '''Relation of endogenous Heinz bodies to disease and anemia in cats: 120 cases (1978 – 1987)'''. J Am Vet Med Assoc, Vol 194 pp. 1089-1095</ref>

* Hyperthyroidism - one study found increased numbers of Heinz bodies in hyperthyroid cats but patients were not significantly anaemic. (<ref name="Christopher"> Christopher M, (1989). '''Relation of endogenous Heinz bodies to disease and anemia in cats: 120 cases (1978 – 1987)'''. J Am Vet Med Assoc, Vol 194 pp. 1089-1095</ref>

* Lymphoma

 

* Lymphoma - an increased percentage of Heinz bodies has been linked with lymphoma in cats. <ref name="Christopher"></ref>

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