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Also known as : '''''PIE — Eosinophilic Lung disease — Eosinophilic Pulmonary Granulomatosis'''''

Also known as : '''''PIE — Eosinophilic Lung disease — Eosinophilic Pulmonary Granulomatosis'''''

==Introduction==

==Introduction==

Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the [[Eosinophils|eosinophil]]. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a [[Category:Hypersensitivity|hypersensitivity]] reaction to an unidentified allergen such as microfilariae of [[Heartworm|heartworms]], [[Lungworm|lungworms]], chronic bacterial or fungal infections (eg, histoplasmosis, [[Aspergillosis|aspergillosis]]), viruses, external antigens, and unknown precipitating factors.<br>  

Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the [[Eosinophils|eosinophil]]. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a [[:Category:Hypersensitivity|hypersensitivity]] reaction to an unidentified allergen such as microfilariae of [[Heartworm|heartworms]], [[Lungworm|lungworms]], chronic bacterial or fungal infections (eg, histoplasmosis, [[Aspergillosis|aspergillosis]]), viruses, external antigens, and unknown precipitating factors.<br>  

'''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterized by the development of nodules and hilar lymphadenopathy. It is most often associated with a hypersensitivity reaction to microfilarie in heartworm infection.  

'''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterized by the development of nodules and hilar lymphadenopathy. It is most often associated with a hypersensitivity reaction to microfilarie in heartworm infection.  

The prognosis is fair to good although there is a wide spectrum of disease severity. Some dogs require long term corticosteroid therapy. ''Eosinophillic Pulmonary Granulomatosis'' carries a guarded prognosis.

The prognosis is fair to good although there is a wide spectrum of disease severity. Some dogs require long term corticosteroid therapy. ''Eosinophillic Pulmonary Granulomatosis'' carries a guarded prognosis.

[[File:CABI logo.jpg|left|90px]]

|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Pulmonary+Infiltration+with+Eosinophilia&occuring1=title&rowId=2&options2=OR&q2=Eosinophilic+Lung+disease&occuring2=title&rowId=3&options3=OR&q3=Eosinophilic+Pulmonary+Granulomatosis&occuring3=title&x=25&y=11&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Pulmonary Infiltration with Eosinophilia publications]

 

 

[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Pulmonary+Infiltration+with+Eosinophilia&occuring1=title&rowId=2&options2=OR&q2=Eosinophilic+Lung+disease&occuring2=title&rowId=3&options3=OR&q3=Eosinophilic+Pulmonary+Granulomatosis&occuring3=title&x=25&y=11&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Pulmonary Infiltration with Eosinophilia publications]

==References==

==References==

* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''

* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''

* Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.

* Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.

[[Category:Allergic Respiratory Diseases]][[Category:Expert_Review]]

[[Category:Allergic Respiratory Diseases]][[Category:Expert_Review]]