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Also known as: '''''Blue-eye''''' — '''''BE''''' — '''''Blue Eye Syndrome''''' — '''''Porcine Paramyxovirus Blue Eye Disease''''' — '''''PPBED''''' —  

Also known as: '''''Blue-eye''''' — '''''BE''''' — '''''Blue Eye Syndrome''''' — '''''Porcine Paramyxovirus Blue Eye Disease''''' — '''''PPBED''''' —  

'''''Porcine Paramyxovirus''''' — '''''Porcine Rubulavirus''''' — '''''Blue Eye Paramyxovirus''''' — '''''BEP''''' — '''''BEPV'''''

'''''Porcine Paramyxovirus''''' — '''''Porcine Rubulavirus''''' — '''''Blue Eye Paramyxovirus''''' — '''''BEP''''' — '''''BEPV'''''

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==Introduction==

==Introduction==

Blue eye disease is caused by the virus '''''Blue-eye paramyxovirus (BEPV)''''', which is a negative sense single stranded RNA (ssRNA) virus. It is closely related to the ''Mumps virus'' and ''Simian virus 5'' and is classified under the family [[:Category:Paramyxoviridae|'''''Paramyxoviridae''''']]. The virus is 135-148nm by 257-360nm, has a bouyant density in sucrose gradients of 1.21 g/ml and is considered to be '''polymorphic''' (but mainly spherical). BEPV envelope is covered in surface projections and the envelope nucleocapsid expresses hemagglutinin-neuraminidase and fusion and matrix proteins. The virus consists of six structural proteins  and is '''resistant''' to  '''actinomycin D''' and '''sensitive''' to '''chloroform, formalin''' and '''beta propiolactone'''.

Blue eye disease is caused by the virus '''''Blue-eye paramyxovirus (BEPV)''''', which is a negative sense single stranded RNA (ssRNA) virus. It is closely related to the ''Mumps virus'' and ''Simian virus 5'' and is classified under the family [[:Category:Paramyxoviridae|'''''Paramyxoviridae''''']]. The virus is 135-148nm by 257-360nm, has a buoyant density in sucrose gradients of 1.21 g/ml and is considered to be '''polymorphic''' (but mainly spherical). BEPV envelope is covered in surface projections and the envelope nucleocapsid expresses hemagglutinin-neuraminidase and fusion and matrix proteins. The virus consists of six structural proteins  and is '''resistant''' to  '''actinomycin D''' and '''sensitive''' to '''chloroform, formalin''' and '''beta propiolactone'''.

It causes '''nervous, reproductive''' and '''respiratory signs''' in its domestic host, the pig. The disease is not considered a zoonosis.

It causes '''nervous, reproductive''' and '''respiratory signs''' in its domestic host, the pig. The disease is not considered a zoonosis.

==Signalment==

==Signalment==

Domestic hosts include dogs, cats and pigs and wild hosts include rabbits, rats, ferral cats and dogs and [http://en.wikipedia.org/wiki/Peccary/ Peccary's].  The '''virus only shows clinical signs in pigs''' but antibodies can be detected in rabbits, rats, dogs and cats.  

Domestic hosts include dogs, cats and pigs and wild hosts include rabbits, rats, ferral cats and dogs and [http://en.wikipedia.org/wiki/Peccary Peccary's].  The '''virus only shows clinical signs in pigs''' but antibodies can be detected in rabbits, rats, dogs and cats.

 

The disease affects '''all age ranges of pigs''' and also causes '''reproductive disorder in the boar'''.

==Clinical Signs==

==Clinical Signs==

'''Generally''' pigs suffer from '''anorexia''', weight loss, '''reluctance to move''', dehydration, periorbital and conjunctival swelling (chemosis) and '''purulent/serous ocular discharge''' and '''corneal opacity'''.  The virus also causes neurological signs including tetraparesis, opisthotonus, dysmetria, proprioceptive disorders, '''tremors''', nystagmus   

'''Generally''' pigs suffer from '''anorexia''', weight loss, '''reluctance to move''', dehydration, periorbital and conjunctival swelling (chemosis) and '''purulent/serous ocular discharge''' and '''corneal opacity'''.  The virus also causes neurological signs including tetraparesis, opisthotonus, dysmetria, proprioceptive disorders, '''tremors''', nystagmus   

'''Piglets and Weaners:'''

'''Piglets and Weaners:'''

Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculation’s, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and  '''constipation/reduction in faeces or diarrhoea'''.

Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculations, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and  '''constipation/reduction in faeces or diarrhoea'''.

'''Sows:'''

'''Sows:'''

==Distribution==

==Distribution==

The disease is economically important to '''Central Mexico and its states'''.

The disease appears restricted to '''Central Mexico and its states'''.

==Diagnosis==

==Diagnosis==

==Treatment==

==Treatment==

There is '''no treatment''' for ''Blue eye disease''. '''Supportive medication''' for respiratory and inflammatory disease should be administered.

There is '''no treatment''' for ''Blue eye disease''. '''Supportive medication''' for respiratory and inflammatory disease should be administered.

==Control==

==Control==

|date = 11 June 2011

|date = 11 June 2011

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[[Category:Pig Viruses]]

[[Category:Pig Viruses]]

[[Category:Paramyxoviridae]]

[[Category:Paramyxoviridae]]

[[category:Neurological Diseases - Pig]][[Category:Respiratory Diseases - Pig]][[Category:Reproductive Diseases - Pig]]

[[category:Neurological Diseases - Pig]][[Category:Respiratory Diseases - Pig]][[Category:Reproductive Diseases - Pig]]

[[Category:CABI Expert Review]]

[[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]]