Changes

 

'''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.  

'''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.  

==Pharmacokinetics==

==Pharmacokinetics==

Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.3%'' and is therefore less potent the other agents. Sevoflurane undergoes a small amount of hepatic metabolism.  

Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.4%'' in dogs and ''2.6%'' in cats and is therefore less potent than other agents. Sevoflurane undergoes a small amount of hepatic metabolism.

==Adverse Effects==

==Adverse Effects==

==Contraindications==

==Contraindications==

*It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.

*It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.