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→Pathogenesis
===''Eschericia coli'' (''E. coli'') overview===
===''Eschericia coli'' (''E. coli'') overview===
[[File:File:Ecoli.jpg|200px|right]]
[[File:Ecoli.jpg|200px|right]]
*Member of ''Enterobacteriacae'' family of Gram-negative bacilli
*Member of ''Enterobacteriacae'' family of Gram-negative bacilli
*'''Facultative anaerobe'''
*'''Facultative anaerobe'''
*Capsular polysaccharides produced by some strains prevent phagocytosis and interfere with complement
*Capsular polysaccharides produced by some strains prevent phagocytosis and interfere with complement
*Endotoxin is a lipolysaccharide component of the cell wall of Gram-negative bacteria, composed of lipid A, a core polysaccharide and various side chains
*Endotoxin is a lipolysaccharide component of the cell wall of Gram-negative bacteria, composed of lipid A, a core polysaccharide and various side chains
*'''Endotoxin''' is realeased when bacteria die, and causes endothelial damage leading to [[Disseminated Intravascular Coagulation|'''disseminated intravascular coagulation''']] and e'''ndotoxic shock'''; it is also a '''pyrogen'''
*'''Endotoxin''' is realeased when bacteria die, and causes endothelial damage leading to [[Disseminated Intravascular Coagulation|'''disseminated intravascular coagulation''']] and '''endotoxic shock'''; it is also a '''pyrogen'''
*Enterotoxins, verotoxins and cytotoxic necrotising factors produced by many pathogenic ''E. coli''; these produce cell damage at their site of action
*Enterotoxins, verotoxins and cytotoxic necrotising factors produced by many pathogenic ''E. coli''; these produce cell damage at their site of action
*'''Alpha-haemolysin''' may increase iron availability for invading organisms
*'''Alpha-haemolysin''' may increase iron availability for invading organisms
*'''Siderophores''' are made by certain pathogenic strains, and are responsible for iron aquisition; they include aerobactin and enterobactin
*'''Siderophores''' are made by certain pathogenic strains, and are responsible for iron aquisition; they include aerobactin and enterobactin
==Extra-intestinal infection==
==Extra-intestinal infection==