The administration of [[opioids]] or [[Local Anaesthetics|local anesthetic drugs]] block central sensitization and [[NSAIDs|nonsteroidal anti-inflammatory drugs (NSAIDs)]] reduce the severity of the peripheral inflammatory response. The combined use of an opioid and an NSAID is more effective than using either drug alone. Local anesthetics (analgesics) can produce complete pain relief by blocking all sensory input from the affected area. | The administration of [[opioids]] or [[Local Anaesthetics|local anesthetic drugs]] block central sensitization and [[NSAIDs|nonsteroidal anti-inflammatory drugs (NSAIDs)]] reduce the severity of the peripheral inflammatory response. The combined use of an opioid and an NSAID is more effective than using either drug alone. Local anesthetics (analgesics) can produce complete pain relief by blocking all sensory input from the affected area. |