Changes

==Introduction==

==Introduction==

Haemorrhagic diseases can be categorised by two different causal mechanisms:

Haemorrhagic diseases can be categorised by two different causal mechanisms:

*Increased vessel fragility which leads to a non-thrombocytopenic [[Haemorrhage_-_Pathology#Purpura|purpura]].

*Increased vessel fragility which leads to a non-thrombocytopenic [[Haemorrhage#Purpura|purpura]].

*Inadequate haemostatic response. This may be caused by [[Platelet Abnormalities|platelet dysfunction or deficiency]], which leads to a primary or secondary thrombocytopenic purpura, or [[Coagulation Factor Deficiency|deficiencies/derangements of clotting factors]].

*Inadequate haemostatic response. This may be caused by [[Platelet Abnormalities|platelet dysfunction or deficiency]], which leads to a primary or secondary thrombocytopenic purpura, or [[Coagulation Factor Deficiency|deficiencies/derangements of clotting factors]].

==Clotting Factor Abnormalities==

==Clotting Factor Abnormalities==

[[Coagulation Factor Deficiency|Deficiencies]] in clotting factors are often the result of congenital deficiency in one or more of the coagulation factors and can lead to ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding - deficiencies are often detected following trauma or surgery. Occasionally bleeding may be spontaneous (e.g. into alimentary or urinary tracts). Deficiencies are often seen as familial inherited problems; [[Coagulation_Factor_Deficiency#Factor_VIII|Haemophilia (factor VIII deficiency)]] is probably the best understood condition.  

[[Coagulation Factor Deficiency|Deficiencies]] in clotting factors are often the result of congenital deficiency in one or more of the coagulation factors and can lead to ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding - deficiencies are often detected following trauma or surgery. Occasionally bleeding may be spontaneous (e.g. into alimentary or urinary tracts). Deficiencies are often seen as familial inherited problems; [[Coagulation_Factor_Deficiency#Factor_VIII|Haemophilia (factor VIII deficiency)]] is probably the best understood condition.  

Other coagulation defects can be induced by disease processes such as angiostrongylosis, vitamin K deficiency (rodenticide poisoning) or disseminated intravascular coagulation (DIC)

 

Other coagulation defects can be induced by disease processes such as [[Angiostrongylosis|angiostrongylosis]], vitamin K deficiency ([[Anticoagulant Rodenticide Toxicity|rodenticide poisoning]]) or disseminated intravascular coagulation ([[Disseminated Intravascular Coagulation|DIC]])

[[Category:Haemorrhagic Diseases|A]]

[[Category:Haemorrhagic Diseases|A]]

[[Category:To Do - Blood]]

[[Category:To Do - Blood]]