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Granulomatous inflammation
Granulomatous inflammation
* ''Mucor'', a fungi, invades the [[The Rumen - Anatomy & Physiology|rumen]] wall, e.g. after damage caused by [[Rumenal Acidosis|rumenal acidosis]].
* ''Mucor'', a fungi, invades the [[Rumen - Anatomy & Physiology|rumen]] wall, e.g. after damage caused by rumenal acidosis.
* Produces chronic ongoing granulomatous rumenitis.
* Produces chronic ongoing granulomatous rumenitis.
* Difficult to diagnose in life.
* Difficult to diagnose in life.
=====Gross=====
=====Gross=====
* Thickening and ulceration of mucosal surface of [[The Rumen - Anatomy & Physiology|rumen]].
* Thickening and ulceration of mucosal surface of [[Rumen - Anatomy & Physiology|rumen]].
** Feels like thick leather.
** Feels like thick leather.
*[[The Rumen - Anatomy & Physiology|Rumen]] wall becomes fibrosed.
*[[Rumen - Anatomy & Physiology|Rumen]] wall becomes fibrosed.
=====Histological=====
=====Histological=====
* Can visualise fungal hyphae in tissue using special stains (PAS),
* Can visualise fungal hyphae in tissue using special stains (PAS),
** Often grow along blood vessels.
** Often grow along blood vessels.
*** May cause thrombosis of small blood vessels, leading to further necrosis (infarction) of [[The Rumen - Anatomy & Physiology|rumen]] wall.[[Category:Forestomach_-_Inflammatory_Pathology]][[Category:Cattle]]
*** May cause thrombosis of small blood vessels, leading to further necrosis (infarction) of [[Rumen - Anatomy & Physiology|rumen]] wall.
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Caused by a fungus of the ''Mucoracae'' family. Causes a granulomatous rumenitis in cattle with sheets of macrophages and '''giant cells''' vvisble on histopathology. Grossly the rumen is thickened and fibrosed and may become ulcerated.
The infection may penetrate the rumen wall leading to a peritonitis. It may also enter blood vessels leading to a thrombosis, infarction and further damage to the vessel wall.
Fungal hyphae are identified histologically with the stain PAS (Periodic acid Schiff) where they stain as purple/red rod like structures.
[[Category:Forestomach_-_Inflammatory_Pathology]][[Category:Gastric Diseases - Cattle]]
[[Category:To_Do_-_Alimentary]][[Category:To Do - Medium]]
[[Category:Arterial_Pathology]]
[[Category:Cardiology Section]]