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===[[Sodium and Water Excess]]===
 
===[[Sodium and Water Excess]]===
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===[[Sodium Excess]]===
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==Abnormal States of Potassium, Magnesium and Calcium Balance==
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===Sodium Excess===
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===[[Hypomagnesaemia]]===
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* Known as "salt poisoning".
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* Occurs sporadically in the U.K. as a group or herd problem in intensive systems.
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* Mainly affects pigs and poultry. 
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* Caused by:
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** Accidental ingestion of excess salt
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*** Either by dietary contamination, or error.
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** Deprivation of water on relatively high salt diets.
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*** This is the more likely scenario.
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* Salt poisioning may be
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** Peracute/ acute
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** Subacute/ chronic
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====Peracute / acute====
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===[[Hypokalaemia]]===
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* Peracute cases are often found dead.
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** Only shock haemorrhages are seen at autopsy. 
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* Acute cases present as abdominal pain, diarrhoea and vomiting.
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** Death occurs in 24 - 48 hours.
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** At autosy, may see:
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*** Shock haemorrhages.
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*** Gut congestion.
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*** Fluid accumulations in body cavities.
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====Subacute / chronic====
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* These cases show nervous signs.
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===Calcium===
** Convulsions
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** Blindness
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** Ataxia
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* Show excessive salivation.
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* May be polyuric.
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* Fluid may accumulate subcutaneouslt and in the abdomen. 
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* Macroscopic findings are inconclusive.
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====Diagnosis====
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* For definitave diagnosis, histological examination is required.
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* '''[[Hypocalcaemia]]''' is most significant.
* On histological examination, the following may be seen:
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** Perineuronal vasculation and cerebral neuronal necrosis.
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***  '''Polio-encephalomalacia'''.
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** Eosinophilic meningoencephalitis.
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** Perivascular oedema in the brain.
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==Abnormal States of Potassium, Magnesium and Calcium Balance==
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* '''[[Hypercalcaemia]]''' is less common.
 
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===Hypomagnesaemia===
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* Magnesium is important for muscular and nervous conduction.
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*Low Mg <sup>++</sup> diets  may induce acute hypo-magnesaemia in lactating cows. 
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** Seen as tremors and convulsions (tetany).
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** For example, poor quality silage.
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* High K<sup>+</sup> diets induce a relative Mg<sup>++</sup> imbalance.
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** For example, lush pasture.
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** Known as "grass staggers".
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** Produces tetany and ataxia, and sometimes cardiac arrest.
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** Only shock haemorrhages can be seen at autopsy; i.e. non-specific findings.
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===Hypokalaemia===
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* Potasstium is important for nervous and muscle conduction, especially in cardiac muscle. 
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* The hypokalaemia is associated with diarrhoea and dehydration in calves.
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** Animals die from cardiac arrest following ventricular dissociation.
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===Calcium===
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* '''Hypocalcaemia''' is most significant. 
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**  "Milk fever" in lactating cattle.
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** Eclampsia (parturient tetany) in bitches. 
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* '''Hypercalcaemia''' is less common.
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** Usually the result of dietary imbalance.
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** Produces metastatic vascular calcification.
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[[Category:Circulatory Disorders - Pathology]]
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[[Category:Vascular Fluid|A]]
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[[Category:Cardiology Section]]
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