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| Also known as: '''''SLE''''' | | Also known as: '''''SLE''''' |
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| ==Introduction== | | ==Introduction== |
− | Systemic Lupus Erythematous is an immune-mediated disease which can affect '''many different organ systems'''. It is an primary autoimmune disease in which the body loses 'self-tolerance' towards autoantigens and mounts an inappropriate attack on various target tissues of the body. The pathology can be attributed to true autoantibody binding, '''immune complex deposition''' causing a [[Type III Hypersensitivity|type III hypersensitivity reaction]], or cell-mediated autoimmunity. | + | Systemic Lupus Erythematous is an immune-mediated disease which can affect '''many different organ systems'''. It is a primary autoimmune disease in which the body loses 'self-tolerance' towards autoantigens and mounts an inappropriate attack on various target tissues of the body. The pathology can be attributed to true autoantibody binding, '''immune complex deposition''' causing a [[Type III Hypersensitivity|type III hypersensitivity reaction]], or cell-mediated autoimmunity. |
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− | The most well-studied autoantibodies formed are the '''Anti-Nuclear Antibodies''' (ANA) which are found in up to 100% of cases reported and are important in the diagnosis of the disease. These target a number of nuclear components, including double-stranded DNA, histones and extractable nuclear antigens. | + | The most comprehensively studied autoantibodies formed are the '''Anti-Nuclear Antibodies''' (ANA) which are found in up to 100% of cases reported and are important in the diagnosis of the disease. These target a number of nuclear components, including double-stranded DNA, histones and extractable nuclear antigens. |
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| The '''aetiology''' of the disease is multifactorial, involving genetics, immunological disorder, viral infection and hormonal and ultraviolet light modulation. | | The '''aetiology''' of the disease is multifactorial, involving genetics, immunological disorder, viral infection and hormonal and ultraviolet light modulation. |
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− | The condition is uncommon in dogs and rare in cats and horses. | + | The condition is uncommon in dogs and rare in cats and horses. |
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| ==Clinical Signs== | | ==Clinical Signs== |
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| {{review}} | | {{review}} |
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| [[Category:Expert Review]] | | [[Category:Expert Review]] |
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| [[Category:Immunological Diseases - Cat]][[Category:Immunological Diseases - Dog]] | | [[Category:Immunological Diseases - Cat]][[Category:Immunological Diseases - Dog]] |
| [[Category:Immunological Diseases - Horse]] | | [[Category:Immunological Diseases - Horse]] |
| + | [[Category:Dermatological Diseases - Dog]] |