Changes

====Pyridoxine====

====Pyridoxine====

Pyridoxine (vitamin B6) is a cofactor in the production of serotonin, and there is evidence that supplementation can alter tryptophan metabolism to produce higher CNS levels of 5-hydroxytryptophan and serotonin in studies involving laboratory animals<ref>Calderón-Guzmána, D., Hernández-Islasa, J.L., Espitia-Vázqueza, I., Barragán-Mejı́aa, G.,  Hernández-Garcı́aa, E., Santamarı́a-del Ángela, D., Juárez-Olguı́nb, H. (2004) Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain. Archives of Medical Research. 35(4).271–274.</ref>. However, the specific effects of this vitamin alone on behaviour in cats and dogs has not been established. Caution should be exercises regarding pyridoxine dose, given that is potentially neurotoxic in overdose<ref>Rao, D.B., Jortner, B.S., Sills, R.C. (2014) Animal models of peripheral neuropathy due to environmental toxicants. ILAR J. 54(3):315-23.</ref>.

Pyridoxine (vitamin B6) is a cofactor in the production of serotonin, and there is evidence that supplementation can alter tryptophan metabolism to produce higher central nervous system (CNS) levels of 5-hydroxytryptophan and serotonin in studies involving laboratory animals<ref>Calderón-Guzmána, D., Hernández-Islasa, J.L., Espitia-Vázqueza, I., Barragán-Mejı́aa, G.,  Hernández-Garcı́aa, E., Santamarı́a-del Ángela, D., Juárez-Olguı́nb, H. (2004) Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain. Archives of Medical Research. 35(4).271–274.</ref>. However, the specific effects of this vitamin alone on behaviour in cats and dogs has not been established. Caution should be exercises regarding pyridoxine dose, given that it is potentially neurotoxic in overdose<ref>Rao, D.B., Jortner, B.S., Sills, R.C. (2014) Animal models of peripheral neuropathy due to environmental toxicants. ILAR J. 54(3):315-23.</ref>.

====Fatty Acids====

====Fatty Acids====