Difference between revisions of "Testicular Feminisation"
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(Redirected page to Intersex#Testicular feminisation) |
(New page: '''''Aetiology''''' * Genotype XY as should be in the male. * Testes develop normally and secrete Androgens and MIH * Foetal genetalia are genetically insensitive to the actions of Androg...) |
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| − | + | '''''Aetiology''''' | |
| + | |||
| + | * Genotype XY as should be in the male. | ||
| + | * Testes develop normally and secrete Androgens and MIH | ||
| + | * Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor. | ||
| + | |||
| + | |||
| + | '''''Consequence''''' | ||
| + | * Wolffian Ducts regress, allowing formation of '''female external genetalia''': | ||
| + | ** Labia | ||
| + | ** Clitoris | ||
| + | ** Vagina | ||
| + | * Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression. | ||
| + | * Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''. | ||
Revision as of 10:52, 3 July 2008
Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.