Difference between revisions of "Adrenogenital Syndrome"

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* Appears male with a '''micropenis and scrotum'''
 
* Appears male with a '''micropenis and scrotum'''
 
* Both male and female internal genitalia
 
* Both male and female internal genitalia
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 +
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[[Image:Sexual Differentiation adrenogenital syndrome.jpg|right|thumb|250px|<small><center> Schematic showing Genetalia in Adrenogenital Syndrome.  Copyright RVC 2008 (Courtesy of Proff.R.Abayesekara (RVC))</center></small>]]

Revision as of 12:09, 3 July 2008

Aetiology

  • Genotype is XX as should be female
  • Ovaries develop normally
  • Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.


Consequence

  • Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
  • Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.


Morphology

  • Appears male with a micropenis and scrotum
  • Both male and female internal genitalia


Schematic showing Genetalia in Adrenogenital Syndrome. Copyright RVC 2008 (Courtesy of Proff.R.Abayesekara (RVC))