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→Antacids
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Gastroprotective drugs are often used for the following reasons:
* Gastric and duodenal ulceration
* Gastritis
* Reflux Oesphagitis
* Rumenal Acidosis
They following are the different classes of drugs that are used as gastroprotectives.
==Antacids==
==Antacids==
These are administered orally and need frequent aministration when given to small animals. They work be chemically neutralising the acidic environment of the stomach.
These are administered orally and need frequent aministration when given to small animals. They work by chemically neutralising the acidic environment of the stomach.
Examples are: '''magnesium carbonate, magnesium hydroxide, magnesium trisilicate, magnesium oxide, aluminium hydroxide''' and '''sodium bicarbonate'''.
Examples are: '''magnesium carbonate, magnesium hydroxide, magnesium trisilicate, magnesium oxide, aluminium hydroxide''' and '''sodium bicarbonate'''.
==Histamine (H<sub>2</sub>) Receptor Antagonists==
==Histamine (H<sub>2</sub>) Receptor Antagonists==
==Binding Agents==
==Binding Agents==
An is example is '''sucralfate''' that is administered orally.
It works by forming a viscous paste in an acidic environment, the binds and protects the mucosal surface. It also stimulates mucus and bicarbonate secretion and the production of prostaglandins.
==Prostaglandin E Analogues==
An example is '''misoprostol''' that is administered orally.
It works by mimicing the endogenously produced prostaglandins that are gastroprotective. This will therefore inhibit H<sup>+</sup> production and increase mucus and bicarbonate production. It will also maintain normal mucosal blood flow.
It should be used when Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are being used, as NSAIDs block prostoglandin formation and so the gastric lining will be more prone to damage.