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Type IV Hypersensitivity (view source)
Revision as of 10:21, 7 November 2015
, 10:21, 7 November 2015no edit summary
==Introduction==
==Introduction==
[[Image:Sensitisation phase Type IV Hypersensitivity.jpg|right|thumb|150px|Sensitisation phase: Type VI hypersensitivity-Brian Catchpole RVC 2008]]
[[Image:Sensitisation phase Type IV Hypersensitivity.jpg|right|thumb|150px|Sensitisation phase: Type IV hypersensitivity-Brian Catchpole RVC 2008]]
[[Image:Delayed type hypersensitivity.jpg|right|thumb|150px|Type VI hypersensitivity-Brian Catchpole RVC 2008]]
[[Image:Delayed type hypersensitivity.jpg|right|thumb|150px|Type IV hypersensitivity-Brian Catchpole RVC 2008]]
Cell mediated hypersensitivity:
Cell mediated hypersensitivity:
|-
|-
| '''Pathogenesis'''
| '''Pathogenesis'''
| [[Type I Hypersensitivity - WikiBlood|Type I]]
| [[Type I Hypersensitivity|Type I]]
| [[Type IV Hypersensitivity - WikiBlood|Type IV]]
| [[Type IV Hypersensitivity|Type IV]]
|-
|-
| '''Time'''
| '''Time'''
* It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']].
* It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']].
* Presently in the UK the animal is culled if it has a positive skin reaction.
* Presently in the UK the animal is culled if it has a positive skin reaction.
==From Pathology==
*Delayed hypersensitivity
*Haptens bind to carrier proteins (mainly epidermal)
*Mediated by sensitised [[T cell differentiation|T-cells]] -> release cytokines +/- recruit lymphocytes
*Used in diagnosis of tuberculosis, histoplasmosis and coccidiomycosis
*Perivascular mononuclear cell accumulation
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{{Jim Bee 2007}}
[[Category:Hypersensitivity]]