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==Introduction==
[[Image:Feline Calcivirus.jpg|right|thumb|200px|<p>Feline calicivirus infection in a cat, showing ulceration, secondary gingivitis, rhinitis, faucitis and hypersalivation. </p>Source: Wikimedia Commons; Author: Kalumet (2005)]]
The normal hosts for this virus are domestic cats and cheetahs. The virus has a high morbidity/low mortality rate, but affected animals can be further compromised by concurrent infection.
The incubation period is 2-10 days.
Clinical signs include:
Clinical signs include:
*Vesicles and ulcers of the oral epithelium (2-5mm)
*Vesicles and ulcers of the oral epithelium (2-5mm)
*Pneumonia
*Pneumonia
Differential Diagnoses may include:
Differential Diagnoses may include:
*Feline Herpes
*[[Feline Herpesvirus 1]]
*Clamydophila felis
*''[[Chlamydophila felis]]''
*Bordetella bronchiseptica
*''[[Bordetella bronchiseptica]]''
Recovery can be followed by '''carrier status'''
Recovery can be followed by '''carrier status'''
==Epidemiology==
FCV is endemic worldwide. Transmission occurs through '''direct contact''' with secretions of carrier cats or '''indirect contact''' via drinking bowls, etc. Clinical disease is most frequently seen in kittens; '''active immunity''' is generally present in animals over 1 year of age. Antigenic variation means that subclinical reinfections can occur. Calicivirus is one of the agents of [[Feline Upper Respiratory Disease Complex|cat flu]].
==Antigenicity==
A single serotype has been identified which typically has antigenic variations.
*Transmission occurs from diseased and recovered (carrier) animals
*Antigenic variation means that subclinical reinfections can occur
Recent strains of the virus have been shown to cause systemic disease, where the initial upper respiratory signs are followed by:
*Severe pyrexia
*Oedema, particularly of the head and limbs
*Skin ulcers
*Icterus and Petchiae
The mortality rate of recently emerging strains can be as high as 50%, and higher in cats over 1 year of age. Conventional vaccinations are thought to be ineffective against these strains.
==Diagnosis==
Clinical signs are non specific with many other differentials. Nasal, conjunctival, or oropharyngeal swabs can be taken for virus isolation. Cytology of affected cells may demonstrate pyknosis (an irreversible condensation of chromatin in the cell nucleus undergoing necrosis or apoptosis) - feline herpes causes cellular swelling and syncytia formation.
==Control==
*Virulent isolate outbreak: quarantine and restrict movement of in contact animals.
*Prevention: Live or dead [[Vaccines|vaccines]] are available that contain broadly cross-reactive strains. [[Vaccines#Cat_Vaccinations|Vaccination]] is often given in combination with feline herpes and panleukopenia virus immunization.
The virus presents a particular concern for catteries due to the epidemiological risk of spread in intensively kept cats.
{{Learning
|flashcards = [[Feline Medicine Q&A 10]]
|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=feline+calicivirus&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&x=41&y=14&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Feline Calicivirus publications]
|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2007/20073085492.pdf '''Cats and calicivirus infection - the evolving pattern of disease.''' Radford, A.; Coyne, K. P.; Dawson, S.; Porter, C. J.; Gaskell, R. M.; Svoboda, M. ; Czech Small Animal Veterinary Association, Prague, Czech Republic, 2006 World Congress Proceedings. 31st World Small Animal Association Congress, 12th European Congress FECAVA, & 14th Czech Small Animal Veterinary Association Congress, Prague, Czech Republic, 11-14 October, 2006, 2006, pp 343-346, 26 ref.]
|Vetstream = [https://www.vetstream.com/felis/Content/Disease/dis60211 Feline Calicivirus disease - Felis]
}}
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[[Category:Caliciviridae]][[Category:Cat Viruses]][[Category:Respiratory Diseases - Cat]]
[[Category:Expert Review]]
[[Category:Respiratory_Viral_Infections]]
[[Category:Other Oral Conditions]]
[[Category:Caliciviridae]][[Category:Cat]]
[[Category:To_Do_-_Viruses]]