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* Systemic use can lead to nephrotoxicity, especially in dogs.
* Systemic use can lead to nephrotoxicity, especially in dogs.
* '''Must not use in renal failure patients''' - as will accumulate in the kidney.
* '''Must not use in renal failure patients''' - as will accumulate in the kidney.
* In man it has been known to be neurotoxix and have neuromuscular blocking effects.
* In man it has been known to be neurotoxic and have neuromuscular blocking effects.
* If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.
* If sulphate salts are used in the drug preperation, pain and necrosis can occur at the injection site.
{{Learning
|Vetstream = [https://www.vetstream.com/canis/Content/Generic/gen00589.asp Polymyxin B]}}