Changes

* They are active against gram-negative rods, including enterobacteriaceae.

* They are active against gram-negative rods, including enterobacteriaceae.

* They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci.

* They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci.

* Reistance is now widespread.

* Resistance is now widespread.

* Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions.

* Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions.

==Pharmacokinetic Considerations==

==Pharmacokinetic Considerations==

* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.

* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.

===Hepatotoxixity===

===Hepatotoxicity===

*some of these casue hepatic necrosis in susceptible animals

*some of these casue hepatic necrosis in susceptible animals

*has been associated with a reduced capability of detoxifying the metabolites

*has been associated with a reduced capability of detoxifying the metabolites

*Doberman Pincher breed appear to be susceptible

*Doberman Pinscher breed appears to be susceptible

[[Category:Hepatotoxicity,_Drug_induced]]

[[Category:Hepatotoxicity,_Drug_induced]]

[[Category:To_Do_-_Clinical]]

[[Category:To_Do_-_Clinical]]