Changes

==Mechanism of Action==

==Mechanism of Action==

The combination of sulphonamide and trimethoprim means that the bacterial nucleotide sythesis pathway is attacked at two seperate points. This produces a bactericidal, time-dependent killing affect. To find out how sulphonamides work click [[sulphonamides|here]] and to discover the same about trimethoprim click [[Trimethoprim|here]].

The combination of sulphonamide and trimethoprim means that the bacterial nucleotide sythesis pathway is attacked at two seperate points. This produces a bactericidal, time-dependent killing affect. To find out how sulphonamides work click [[sulphonamides|here]] and to discover the same about trimethoprim click [[Trimethoprim - Dihydrofolate Reductase Inhibitors|here]].

 

==Spectrum of Activity==

==Spectrum of Activity==

These drugs are relatively safe and have wide safety margins in all species except in cats. Again look at the individual drug combinations for specific mixture side-effects. Concern has been noted about immune-mediated reactions in dogs.

These drugs are relatively safe and have wide safety margins in all species except in cats. Again look at the individual drug combinations for specific mixture side-effects. Concern has been noted about immune-mediated reactions in dogs.