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| | + | |pagetitle =Paramyxoviridae |
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| − | ==Morphology== | + | <categorytree mode=pages>Paramyxoviridae</categorytree> |
| − | *Single-stranded negative-sense unsegmented RNA virus
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| − | *Reassortment and antigenic shift cannot occur
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| − | *Spike proteins include
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| − | **'''HN''' (Haemagglutinin and Neuraminidase)
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| − | **'''F''' (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA
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| − | ***F also causes syncitium to form, which aids diagnosis
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| − | ***Host antibody response to the F protein is the basis for vaccination
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| − | ==Virulence==
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| − | *Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut
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| − | **Sites of spike protein cleavage
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| − | *Virulence varies by virus, see below
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| − | ===Types and Subtypes== | + | {{Learning |Vetstream = <p>[https://www.vetstream.com/canis/Content/Bug/bug00215.asp Canine Distemper]</p><p>[https://www.vetstream.com/canis/Content/Bug/bug00210.asp Canine Parainfluenza Virus 2]</p>}} |
| − | Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including:
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| − | *Subfamily: ''[[Paramyxovirinae]]'':
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| − | *Subfamily: ''Pneumovirinae''
| + | [[Category:Viral Organisms]] |
| − | **[[Paramyxoviridae#Bovine Respiratory Syncytial Virus (BRSV)|Bovine Respiratory Syncytial Virus (BRSV)]]
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| − | **Turkey Rhinotracheitis Virus
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| − | ==Antigenic Variation==
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| − | *Antigenic conservation allows some cross protection by vaccination:
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| − | **Conservation of major virus-specific F/HN antigens means vaccines protect against '''all isolates''' of the same virus
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| − | **Minor morbillivirus-specific epitopes on F allows some cross protection between '''canine distemper, measles, and rinderpest'''
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| − | *Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
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| − | **These are detected by immunostaining infected cells
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| − | ==Paramyxoviridae by Species==
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| − | ==Avian==
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| − | ===[[Newcastle Disease Virus (NDV)]]===
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| − | ==Canine==
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| − | ===[[Canine Parainfluenza - 2 (aka Parainfluenza - 5)]]===
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| − | ===[[Canine Distemper Virus (CDV)]]===
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| − | ==Bovine==
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| − | ===[[Bovine Parainfluenza - 3 (PI-3)]]===
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| − | ===[[Bovine Respiratory Syncytial Virus (BRSV)]]===
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| − | ==Equine==
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| − | ===[[Hendra Virus]]===
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| − | ==Porcine==
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| − | ===Nipah Virus===
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| − | *Infects pigs and humans
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| − | *Humans exposed to pig blood are at risk
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| − | *Causes porcine respiratory and neurologic syndrome in pigs
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| − | *Zoonosis transmitted by fruit bats
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| − | *Nipah virus is an emerging disease with the first outbreak in 1999 in Malaysia
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| − | ==Reptiles==
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| − | ===Reptilian Paramyxoviruses===
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| − | *Infect central nervous system and lungs
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| − | *Kill particularly '''snakes'''
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| − | *Healthy reptiles may be carriers
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| − | *Testing by serology - '''HI test'''
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| − | *Aim to keep virus free collection and prevent spread back into the wild
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| − | ==Rodentia==
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| − | ===Murine Parainfluenza - 1 (Sendai virus)===
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| − | *Endemic in many '''mouse''' colonies
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| − | *Most mice show no symptoms due to maternal antibodies
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| − | *But minor respiratory lesions may invalidate carcinogenic or toxicological studies
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| − | *Immunological studies also confused due to virus activating [[Lymphocytes - WikiBlood#Natural Killer (NK) Cells|NK cells]] via high circulating [[Innate Immune System - WikiBlood#Interferons|IF]] 3-4 days post-infection
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| − | *Control achieved by:
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| − | **Purchasing '''specific pathogen free (SPF)''' mice
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| − | **Kill whole colony in an outbreak -> disinfection -> formalin fumigation
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| − | =Other resources=
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| − | *[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
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| − | [[Category:Viruses]] | |
