Difference between revisions of "Category:Retroviridae"

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|pagebody = Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression.
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{{Learning |Vetstream = <p>[https://www.vetstream.com/felis/Content/Bug/bug60015.asp Feline Immunodeficiency Virus]</p><p>[https://www.vetstream.com/felis/Content/Bug/bug60014.asp Feline Leukemia Virus]</p>}}
  
=Introduction=
 
Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression.
 
  
=Morphology=
 
*Fragile, enveloped RNA viruses with roughly spherical spike proteins
 
*Genome has 3 genes:
 
**''gag'': group-specific antigen coding gene, encodes capsid proteins
 
**''pol'': encodes reverse transcriptase (RT) and integrase
 
**''env'': encodes envelope spikes, and can be used in diagnosis and subunit vaccines
 
*Both ends of genome show a promoter (LTR: long terminal repeat)
 
  
=Antigenicity=
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[[Category:Viral Organisms]]
*Group-specific antigens (gag's) are shared by all isolates of each virus
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[[Category:To_Do_-_Clinical/Viruses]]
**This can be exploited by diagnostic tests
 
*Lentiviruses show variation by mutation, making vaccination difficult
 
 
 
=Virulence and Pathogenesis=
 
*Replication involves integrating into the host cell genome:
 
**'''Uncoating''' to release RNA and RT
 
**+RNA '''transcribed''' to -DNA by RT
 
**-DNA becomes circular dsDNA and is '''integrated''' into host chromosome by integrase
 
**DNA '''codes''' for viral proteins using cellular organelles and enzymes
 
**Because of this technique, virus replication is much '''slower''', and retroviruses can remain '''latent'''
 
*Tumor production takes 2 forms:
 
**Viruses can carry oncogenes within their genome --> tumor production occurs quickly
 
**Insertion of the viral LTR switches on proto-oncogenes in the host cell genome --> tumor production can take years
 
 
 
=Types and Subtypes=
 
7 Genera, including these of veterinary relevance:
 
 
 
[[Mammalian Type C retrovirus]]
 
 
 
[[Mammalian Type D retrovirus]]
 
 
 
[[Avian Type C retrovirus]]
 
 
 
[[Spumavirus]]
 
 
 
BLV-HTLV retroviruses
 
*Bovine Leukosis Virus
 
 
 
[[Lentiviruses]]
 
 
 
[[Category:Viruses]]
 

Latest revision as of 00:09, 16 June 2016

Retroviridae

Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression.



Retroviridae Learning Resources
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Vetstream
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Canis, Felis, Lapis or Equis


Subcategories

This category has the following 3 subcategories, out of 3 total.

Pages in category "Retroviridae"

The following 4 pages are in this category, out of 4 total.