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==Introdcution==
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==Introduction==
Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli,  
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Amyloid infiltration occurs in all species - amyloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli,  
 
[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords).
 
[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords).
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Affected organs are non-functional and appear waxy and pale.
 
Affected organs are non-functional and appear waxy and pale.
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==Test yourself with the Vascular Pathology Flashcards==
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[[Vascular_Pathology_Flashcards_-_Pathology|Vascular Pathology Flashcards]]
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*Amyloid is an insoluble protein that can accumulate in the kidney and compress the glomerulus, interfering with its normal function.
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*Hypoproteinaemia and nephrotic syndrome can result due to substantial protein loss in the urine.
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*Causes can be idiopathic or associated with underlying chronic inflammatory conditions.
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'''Gross pathology'''
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*Kidneys are firm, enlarged, and pale.  Affected glomeruli may be seen as yellowish spots in the cortex.
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*Amyloid can be visualised by treating the freshly cut surface of the kidneys with iodine.
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'''Histopathology'''
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*Amyloid stains pink with congo red.
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*Presence of a pink, homogenous material replacing the epithelium and endothelium of the glomerulus.
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<center><gallery>
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Image:Congo red.jpg|'''Amyloidosis Stained with Congo Red''' <br> Susan Rhind, University of Edinburgh
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Image:Amyloidosis_histology.jpg|'''Amyloidosis Histology''' <br> Susan Rhind University of Edinburgh
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</gallery></center>
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{{Learning
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|Vetstream = [https://www.vetstream.com/canis/search?s=amyloidosis Amyloidosis]
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|flashcards=[[Vascular Pathology Flashcards|Vascular Pathology]]
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}}
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[[Category:Liver_-_Storage_Diseases]]
 
[[Category:Liver_-_Storage_Diseases]]
    
[[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]]
 
[[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]]
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[[Category:Glomerular Disease]]
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[[Category:To Do - Urinary]][[Category:Cardiology Section]]
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