Changes

'''First Generation Cephalosporins''' - Cefalexin, Cefalonium

'''First Generation Cephalosporins''' - Cefalexin, Cefalonium, Cephapirin

* Active against gram positive organisms

* Active against gram positive organisms

* Active aginst many gram negatives. ''Pseudomonas'' species are resistant.

* Active aginst many gram negatives. ''Pseudomonas'' species are resistant.

'''Second Generation Cephalosporins''' - Ceftiofur

'''Second Generation Cephalosporins''' - Cefuroxime

* Very broad spectrum with very high activity against enterobacteriaeceae.

* Very broad spectrum with very high activity against enterobacteriaeceae.

* Struggle against the most difficult gram negative organisms

* Struggle against the most difficult gram negative organisms

'''Third Generation Cephalosporins''' - Cefoperazone

'''Third Generation Cephalosporins''' - Cefoperazone, Ceftiofur

* Very active against gram negatives, especially the hardier species, including ''Pseudomonas''

* Very active against gram negatives, especially the hardier species, including ''Pseudomonas''

* Less active against gram positives compared to other cephalosporins; Staphylococci and enterococci can be resistant.

* Less active against gram positives compared to other cephalosporins; Staphylococci and enterococci can be resistant.

'''Fourth Generation Cephalosporins''' - Cefquinome

'''Fourth Generation Cephalosporins''' - Cefquinome

* Very broad spectrum, only the very hardiest of gram negatives aren't susceptible. It is still active againts ''Pseudomonas''.

* Very broad spectrum, only the very hardiest of gram negatives aren't susceptible. It is still active against ''Pseudomonas''.

 

==Pharmacokinetic Considerations==

==Pharmacokinetic Considerations==

* Very high doses has been known to result in nephrotoxicity.

* Very high doses has been known to result in nephrotoxicity.

* They can result in bleeding problems because of interference with the formation of vitamin K in the gut (esp Moxalactam).

* They can result in bleeding problems because of interference with the formation of vitamin K in the gut (esp Moxalactam).