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|linkpage =WikiDrugs

|linkpage =WikiDrugs

==Mechanisms of Resistance==

==Mechanisms of Resistance==

This is still an area of research, but most methods of resistance seem to revolve around a reduced binding site affinity. For [[benzimidazoles]] it seems that there is less affinity to the tubulin binding site. [[Macrocyclic Lactones]] seem to have increased expression of a non-specific transmembrane efflux pump that can eject toxins out of thenematode.

This is still an area of research, but most methods of resistance seem to revolve around a reduced binding site affinity. For [[benzimidazoles]] it seems that there is less affinity to the tubulin binding site. [[Macrocyclic Lactones]] seem to have increased expression of a non-specific transmembrane efflux pump that can eject toxins out of the nematode.

 

==Investigating Resistance==

==Investigating Resistance==

'''Molecular Techniques'''

'''Molecular Techniques'''

RFLP assay and a specific PCR-reaction have been made to test for [[benzimidazole]] resistance.

RFLP assay and a specific PCR-reaction have been made to test for [[benzimidazoles|benzimidazole]] resistance.

 

==Development of Resistance==

==Development of Resistance==

For more information on sustainable co

For more information on managing parasites in sheep please look at the Sustainable Control of Parasites in Sheep (SCOPS) website; http://www.nationalsheep.org.uk/index.php?option=com_content&task=view&id=287&Itemid=68