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==Introduction==

==Introduction==

The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper VirusZcanine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petit Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.

The Paramyxoviridae have a helical nucleocapsid surrounded by an envelope comprised of host cell membrane spiked with viral glycoproteins responsible for haemagglutinin, neuraminidase and haemolytic activities. The genome of the Paramyxoviridae is single-stranded, negative-sense RNA which is used as a template for the production of messenger (positive-sense) RNA and further genomic material. Paramyxoviridae are sensitive to heat, dessication and most disinfectants, and so are not resistant in the environment. The Paramyxovididae family is divided to two sub-families, the [[Paramyxovirinae]] and the [[Pneumovirinae]]. It is within the Paramyxovirinae sub-family that [[morbilliviruses]] fall, along with respiroviruses, henipaviruses, rubulaviruses and avulaviruses. As well as [[Canine Distemper Virus|canine distemper virus (CDV)]], the morbilliviruses include [[rinderpest]], [[Peste des Petits Ruminants|peste des petits ruminants]], measles, phocine (seal) distemper and dolphin distemper.

==Morphology==

==Morphology==

==Types and Subtypes==

==Types and Subtypes==

Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including the subfamily ''[[Paramyxovirinae]]'' and subfamily ''[[Pneumovirinae]]''.

Paramyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including the subfamily ''[[Paramyxovirinae]]'' and subfamily ''[[Pneumovirinae]]''.

==Antigenic Variation==

==Antigenic Variation==

Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies. These are detected by immunostaining infected cells.

Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies. These are detected by immunostaining infected cells.

=Other resources=

==Other resources==

*[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]

*[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]

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[[Category:Expert_Review]]

[[Category:Expert_Review]]

[[Category:Paramyxoviridae]]

[[Category:Paramyxoviridae|A]]