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==Introduction==
 
==Introduction==
 
'''Heinz bodies''' are inclusion bodies that form within erythrocytes as a result of '''oxidative injury''' to the cell. Named after Robert Heinz, the German physician who first described them, they consist of precipitated haemoglobin and their presence can result in premature phagocytosis of erythrocytes <ref name="Schalm"> Weiss, D and Wardrop, K (eds) (2010) '''Schalm's Veterinary Haematology, Sixth edition''' Wiley-Blackwell p. 134</ref>  
 
'''Heinz bodies''' are inclusion bodies that form within erythrocytes as a result of '''oxidative injury''' to the cell. Named after Robert Heinz, the German physician who first described them, they consist of precipitated haemoglobin and their presence can result in premature phagocytosis of erythrocytes <ref name="Schalm"> Weiss, D and Wardrop, K (eds) (2010) '''Schalm's Veterinary Haematology, Sixth edition''' Wiley-Blackwell p. 134</ref>  
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Oxidative toxins damage the sulphydryl groups of the globin chains of haemoglobin resulting in the formation of Heinz bodies (HBs). These are seen as unstained projections on the cell membrane with Romanowsky stain, but stain with new methylene blue. Oxidative injury may also result in eccentrocyte formation +/- methaemoglobinaemia (see below). Many substances can cause oxidative damage. Affected cells may be phagocytosed in the spleen or, if severely damaged, may undergo haemolysis within the circulation - there may be both extravascular and intravascular haemolysis. This type of anaemia is regenerative. References: [[NationWide Laboratories]]
      
===Structure of haemoglobin===
 
===Structure of haemoglobin===
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== References ==
 
== References ==
 
<references/>
 
<references/>
 
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[[Category:Anaemia|8]]
 
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[[Category:Anaemia]]
 

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