Changes

Also known as '''''Blood Urea Nitrogen - BUN

Also known as '''''Blood Urea Nitrogen — BUN

==Description==

==Description==

Urea is a form of nitrogenous waste formed from [[Ammonia|ammonia]] via the urea cycle in the liver.  It freely crosses lipid membranes and is filtered into the glomerular filtrate in the renal glomerulus.  A proportion of this filtered urea is reabsorbed passively before final excretion and it forms a vital of the concentration gradient needed to prevent passive diuresis.

Urea is a form of nitrogenous waste formed from [[Ammonia|ammonia]] via the urea cycle in the liver.  It freely crosses lipid membranes and is filtered into the glomerular filtrate in the renal glomerulus.  A proportion of this filtered urea is reabsorbed passively before final excretion and it forms a vital of the concentration gradient needed to prevent passive diuresis.

==Clinical Significance==

==Clinical Significance==

An increase in serum concentrations of urea and creatinine is known as '''[[Azotaemia|azotaemia]]''' and it is found almost exclusively in animals with kidney disease.

An increase in serum concentrations of urea and creatinine is known as '''[[Azotaemia|azotaemia]]''' and it is found almost exclusively in animals with kidney disease.

*Reduced synthesis with [[Portosystemic Shunt|porto-systemic shunts]], [[Hepatic Microvascular Dysplasia|microvascular dysplasia]] or liver failure.

*Reduced synthesis with [[Portosystemic Shunt|porto-systemic shunts]], [[Hepatic Microvascular Dysplasia|microvascular dysplasia]] or liver failure.

*A diet with a low protein content or malnutrition.

*A diet with a low protein content or malnutrition.

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[[Category:Blood Biochemistry Changes]][[Category:To_Do_-_Blood]]

[[Category:Blood Biochemistry Changes]][[Category:To_Do_-_Blood]]